Q6RI63
Gene name |
Fam120b (Ccpg, Kiaa1838) |
Protein name |
Constitutive coactivator of peroxisome proliferator-activated receptor gamma |
Names |
Constitutive coactivator of PPAR-gamma, Constitutive coactivator of PPARG, Protein FAM120B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67544 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6RI63
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6RI63-F1 | Predicted | AlphaFoldDB |
43 variants for Q6RI63
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389427883 | 73 | N>K | No | EVA | |
| rs3389450418 | 105 | R>T | No | EVA | |
| rs3389435115 | 114 | K>N | No | EVA | |
| rs3389450401 | 127 | G>C | No | EVA | |
| rs3389444322 | 159 | A>T | No | EVA | |
| rs48638411 | 169 | Q>E | No | EVA | |
| rs3389433032 | 191 | F>S | No | EVA | |
| rs3389384028 | 193 | I>F | No | EVA | |
| rs864288146 | 204 | I>T | No | EVA | |
| rs3389414876 | 227 | C>Y | No | EVA | |
| rs3389384045 | 231 | N>K | No | EVA | |
| rs3389450429 | 233 | I>N | No | EVA | |
| rs3389435130 | 241 | S>C | No | EVA | |
| rs3389403127 | 245 | K>Q | No | EVA | |
| rs3389429030 | 260 | K>E | No | EVA | |
| rs3389433004 | 280 | G>C | No | EVA | |
| rs3389433047 | 282 | K>N | No | EVA | |
| rs3389427850 | 295 | A>P | No | EVA | |
| rs3389348493 | 316 | Q>* | No | EVA | |
| rs3389403168 | 327 | Q>L | No | EVA | |
| rs3389429046 | 328 | M>K | No | EVA | |
| rs3389444339 | 349 | Q>R | No | EVA | |
| rs3389348448 | 356 | N>S | No | EVA | |
| rs3389433421 | 364 | P>S | No | EVA | |
| rs3389426535 | 450 | S>T | No | EVA | |
| rs3389433053 | 454 | I>F | No | EVA | |
| rs3389433067 | 472 | N>K | No | EVA | |
| rs3389435160 | 478 | E>K | No | EVA | |
| rs3389435140 | 480 | E>G | No | EVA | |
| rs3389384006 | 515 | W>* | No | EVA | |
| rs3389450411 | 526 | K>E | No | EVA | |
| rs3389384013 | 529 | F>L | No | EVA | |
| rs3389393335 | 535 | S>P | No | EVA | |
| rs50939237 | 549 | V>I | No | EVA | |
| rs3389383995 | 573 | D>V | No | EVA | |
| rs3389450416 | 611 | T>S | No | EVA | |
| rs3389450469 | 639 | Q>H | No | EVA | |
| rs3389393370 | 644 | N>D | No | EVA | |
| rs3389437450 | 701 | V>M | No | EVA | |
| rs3389393364 | 714 | K>N | No | EVA | |
| rs262895586 | 738 | H>R | No | EVA | |
| rs3389444279 | 774 | G>W | No | EVA | |
| rs864284606 | 783 | W>R | No | EVA |
No associated diseases with Q6RI63
No regional properties for Q6RI63
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6RI63 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. |
| peroxisome proliferator activated receptor signaling pathway | The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96EK7 | FAM120B | Constitutive coactivator of peroxisome proliferator-activated receptor gamma | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVRGLQGFV | GSTCPHICTI | VNIHELAERH | RNKYPGCTPT | IVVDAMCCLR | YWYTAESWVC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGQWREYYCA | LRNFVAAFTS | AGIKLIFFFD | GMVEPGKRDE | WVKRRLKNNR | EISKIFHYIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKRDQPGRNM | FFIPSGLAIF | TRFALKTLGQ | ETFCSLQEAD | YEVASYGLQH | NCLGILGEDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYLIYDTCPY | FSIGDLCLES | LQTIMLCREK | LCESLGLRVA | DLPLLACLLG | NDITPESMFE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFRYKCLSSY | ASVKENAGKK | GNIILAVSDY | ISKVLHLYQG | EKKIEEMLPL | GPNKALFYKG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTSYLLPGQK | SPWLVQKPKG | MITDKQQMVS | LNPESKQEVP | MCIDPEFKQE | VPVCTNPESM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QEVPMCMDPE | PNQEASMCTD | PESKQEVPMC | TDSESKPEVS | QYTNPESKQK | LPSGIDTEFN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEALMCTHPE | FKQEDVMDME | PEIKQVTMVS | ESEILKVARM | HHVHSESYLV | YNILSSGEIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CSNTLEDELD | QALPSQAFIY | RPVRQRVYAL | LLGDWKDGAS | TGPVVKEWFV | YPGNSLKHPD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVRPLQMTVQ | GGTPSLEVLW | LSQEPAVQAQ | RLDTLLACFN | LSSSREELQA | VESPLRALCC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LLIYLFVQVD | TLSLEDLHAF | IAQALCLQGK | STSQLMHLQL | DYINSRAVQL | GSLLVRGLTT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVLVNSACGF | PWTTSEFMPW | NVFDGKLFHQ | KYLQSEKGYA | VEVLLEQNRS | WLTKFHNLKA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVCKACSKEN | RRIVGRTHWD | SPYTGRQGRQ | GYSSYRTDST | HGHSGQSWRN | QGSGGRQHER |
| NHWRRY |