Q6Q0N0
PR
Gene name |
Clstn1 (Cs1) |
Protein name |
Calsyntenin-1 |
Names |
Alcadein-alpha, Alc-alpha |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:313717 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6Q0N0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6Q0N0-F1 | Predicted | AlphaFoldDB |
No variants for Q6Q0N0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6Q0N0 | |||||
No associated diseases with Q6Q0N0
Functions
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of spine apparatus membrane | The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic endosome | An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| amyloid-beta binding | Binding to an amyloid-beta peptide/protein. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| X11-like protein binding | Binding to X11-like protein, a neuron-specific adaptor protein. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| neurotransmitter receptor transport to postsynaptic membrane | The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| positive regulation of synaptic transmission | Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of synapse maturation | Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. |
| vesicle-mediated transport in synapse | Any vesicle-mediated transport that occurs in a synapse. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRRPAPALA | RAVRLLLAGL | LYGGGVWAAR | VNKHKPWLEP | TYHGIVTEND | NTVLLDPPLI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALDKDSPLRF | AGEICGFKIH | GQNVPFDAVV | VDKSTGEGII | RSKEKLDCEL | QKDYTFTIQA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YDCGKGPDGT | GVKKSHKATV | HIQVNDVNEY | APVFKEKSYK | AAVVEGKQHG | SILRVEAVDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DCSPQFSQIC | SYEILTPDVP | FTVDKDGYIK | NTEKLNYGKE | HQYKLTVTAY | DCGKKRATED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLVKISVKPT | CSPGWQGWSS | RIEYEPGTGA | LAVFPSIHLE | TCDEPVASVQ | ATVELETSHI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKGCDRDTYS | EKSLHRLCGA | AAGTSELLPS | PSSSFNWTVG | LPTDNGHDSD | QVFEFNGTQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VRIPDGVVTL | DPKEPFTISV | WMRHGPFGRK | KETILCSSDK | TDMNRHHYSL | YVHGCRLIFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LRQDPSEEKK | YRPAEFHWKL | NQVCDEDWHH | FVLNVEVPSV | TLYVDGVSHE | PFSVTEDYPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HPTKIETQLV | VGACWQGGDL | HMTQFFRGNL | AGLTVRSGKL | ADKKVIDCLY | TCKEGLDLQV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PEDGNRGVQI | QTSSSQAVLT | LEGENVGELD | KAMQHISYLN | SRQFPTPGIR | RLKITSTVKC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FNEAACIEVP | PVEGYVMVLQ | PEEPKISLSG | VHHFARAASE | FESPEGVSLF | PELKIISTIT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| REVEPEADGA | EDPTVQESLV | SEEIVHDLDT | CEVTVEGEEL | NAEQESLEVD | VARLQQKGIE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VNHSDLGVVF | TGVETMASYE | EVLHLLRYRN | WHTRSLLDRK | FKLICSELNG | RYLSNEFKVE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VNVIHTANPV | EHANHMAAQP | QFVHPEHRSF | VDLSGHNLAS | PHPFAVVPST | ATVVIVVCVS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FLVFMIILGV | FRIRAAHQRT | MRDQDTGKEN | EMDWDDSALT | ITVNPMETYE | DQHSSEEEEE |
| 910 | 920 | 930 | 940 | 950 | |
| EEEEEESEDG | EEEEDITSAE | SESSEEEEGG | PGDGQNTTRQ | QQLEWDYSTL | SY |