Q6PGR9

PR
Gene name
trim72 (mg53)
Protein name
Tripartite motif-containing protein 72
Names
Mitsugumin-53, Mg53
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379612
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PGR9

Entry ID Method Resolution Chain Position Source
AF-Q6PGR9-F1 Predicted AlphaFoldDB

No variants for Q6PGR9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6PGR9

No associated diseases with Q6PGR9

11 regional properties for Q6PGR9

Type Name Position InterPro Accession
domain B-box-type zinc finger 83 - 124 IPR000315
domain Zinc finger, RING-type 16 - 59 IPR001841
domain B30.2/SPRY domain 272 - 476 IPR001870
domain SPRY domain 343 - 473 IPR003877
domain Butyrophylin-like, SPRY domain 289 - 306 IPR003879-1
domain Butyrophylin-like, SPRY domain 306 - 323 IPR003879-2
domain Butyrophylin-like, SPRY domain 328 - 352 IPR003879-3
domain Butyrophylin-like, SPRY domain 358 - 371 IPR003879-4
domain Butyrophylin-like, SPRY domain 404 - 428 IPR003879-5
domain SPRY-associated 290 - 342 IPR006574
conserved_site Zinc finger, RING-type, conserved site 31 - 40 IPR017907

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane, sarcolemma
  • Cytoplasmic vesicle membrane
  • Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

3 GO annotations of molecular function

Name Definition
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
plasma membrane repair The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTPQLMQGM QKDLTCQLCL ELFRAPVTPE CGHTFCQGCL TGVPKNQDQN GSTPCPTCQS
70 80 90 100 110 120
PSRPETLQIN RQLEHLVQSF KQVPQGHCLE HMDPLSVYCE QDKELICGVC ASLGKHKGHN
130 140 150 160 170 180
IITASEAFAK LKRQLPQQQV ILQEARLKKE KTVAVLDRQV AEVQDTVSRF KGNVKHQLNA
190 200 210 220 230 240
MRSYLNIMEA SLGKEADKAE SAATEALLVE RKTMGHYLDQ LRQMEGVLKD VEGQEQTEFL
250 260 270 280 290 300
RKYCVVAARL NKILSESPPP GRLDIQLPII SDEFKFQVWR KMFRALMPAL ENMTFDPDTA
310 320 330 340 350 360
QQYLVVSSEG KSVECADQKQ SVSDEPNRFD KSNCLVSKQS FTEGEHYWEV IVEDKPRWAL
370 380 390 400 410 420
GIISETANRK GKLHATPSNG FWIIGCKEGK VYEAHTEQKE PRVLRVEGRP EKIGVYLSFS
430 440 450 460 470
DGVVSFFDSS DEDNLKLLYT FNERFSGRLH PFFDVCWHDK GKNSQPLKIF YPPAEQL