Q6PCP5

PR
Gene name
Mff
Protein name
Mitochondrial fission factor
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75734
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

109-214 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PCP5

Entry ID Method Resolution Chain Position Source
AF-Q6PCP5-F1 Predicted AlphaFoldDB

8 variants for Q6PCP5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3390249426 7 I>T No EVA
rs3388483471 29 V>A No EVA
rs3388482195 32 P>S No EVA
rs255435573 110 L>P No EVA
rs3388484607 169 N>K No EVA
rs3388482076 202 V>M No EVA
rs3388484544 239 V>E No EVA
rs580786331 276 I>M No EVA

No associated diseases with Q6PCP5

1 regional properties for Q6PCP5

Type Name Position InterPro Accession
domain Methyltransferase domain 25 136 - 238 IPR041698

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein
  • Peroxisome
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.

4 GO annotations of molecular function

Name Definition
GTPase binding Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein-containing complex binding Binding to a macromolecular complex.

14 GO annotations of biological process

Name Definition
mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
mitochondrial fragmentation involved in apoptotic process The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.
mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment.
mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized.
peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.
positive regulation of cardiac muscle cell apoptotic process Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
positive regulation of release of cytochrome c from mitochondria Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
positive regulation of synaptic vesicle endocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis.
protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.
regulation of mitochondrion organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
regulation of peroxisome organization Any process that modulates the frequency, rate or extent of peroxisome organization.
release of cytochrome c from mitochondria The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GZY8 MFF Mitochondrial fission factor Homo sapiens (Human) PR
10 20 30 40 50 60
MAEISRIQYE MEYTEGISQR MRVPEKLKVA PPNADLEQEF QDGVPNASVI MQVPERIVVT
70 80 90 100 110 120
GNNEDISFSR PADLDLIQST PFKPLALKTP PRVLTLSERP LDFLDLERPL PTPQSEESRA
130 140 150 160 170 180
VGRLKRERSM SENAVRQNGQ LVRNDSIVTP SPPQARVCPP HMLPEDGANL SSARGILSLI
190 200 210 220 230 240
QSSTRRAYQQ ILDVLDENRR PVLRGGSAAA TSNPHHDNVR YGISNLDAAI EGASDDMTVV
250 260 270 280 290
DAASLRRQII KLNRRLQLLE EENKERAKRE MVMYSITVAF WLLNSWLWFR R