Q6P9I7
Gene name |
smc6 (smc6l1) |
Protein name |
Structural maintenance of chromosomes protein 6 |
Names |
SMC protein 6, SMC-6, xSMC6 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:398986 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P9I7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P9I7-F1 | Predicted | AlphaFoldDB |
No variants for Q6P9I7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6P9I7 | |||||
No associated diseases with Q6P9I7
1 regional properties for Q6P9I7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RecF/RecN/SMC, N-terminal | 88 - 1103 | IPR003395 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
| Smc5-Smc6 complex | A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular senescence | A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| telomere maintenance via recombination | Any recombinational process that contributes to the maintenance of proper telomeric length. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKRKDGSPI | APSSQRKKQR | QEVDDPYDEE | DYGQAGPSVS | NDYGQRKKQR | KEADNSHTDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYENSVSCAS | SQRVSASQSG | TGDVGIIESI | FLRNFMCHSM | LGPFRFGPNV | NFVIGNNGSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSAVLTALIV | GLGGKAAITN | RGSSIKGFVK | EGQTFAEISI | TLRNRGQDAY | KPDVFGNSIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQQRLTTDGS | RTYKLKSATG | AVVSNKKEEL | TAILDHFNIQ | VDNPVSVLTQ | EMSKHFLQSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NESDKYKFFM | KATQLEQMKE | DYSYIMETKS | RTHDQVENGG | ERLRDLRQEC | IQKEERFKSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASLGEMKEKL | EDLKNKMAWA | LVTESEKQIK | PFIEQISTEE | GRTVKYEQKI | EECQGKVINA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEKFRAKQEE | LDKITQEAVA | LKPQGIGLKE | DVQKKRKSYN | ESEVLYNRHR | MELKRLERDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EQLHKRIEEL | KKSADNDSES | EKMARQKEIN | QIRERMKALH | DKDITTNQQI | HQFQQAIEKY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEERARIGNE | ERNIKQRLEQ | HKRQLKELHE | SKTDRLKRFG | QNMPALLAAI | DEADKLGRFR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKPVGPLGAC | IHLKDQELAL | AVESCLKGLM | FAFCCDNHQD | ERMLQNIMSR | EYPRGRRPQI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IVNEFIDHVY | DVRQRATFHP | DHPTVLTALE | IDHPVVTNCL | IDMRGIETIL | IIKGKDEARE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IMQKRAPPRN | CREAFTGEGD | QVYTNRYYSS | DSRRATLLSR | DVEAEISHLE | KELRNFGSQM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ATFQQRAQSV | DKDIKENEGI | LRQYHNSKKQ | IQIDLRPLLE | RISELENVEE | QPSIDIATLE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GEAEENLNKI | ELVKQEVELA | KEKMGNLKSF | LTTAEINYEE | IKKKISSVAE | VAEPVKEDLH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RVDQEVENCK | RHRKHYEEKL | KEHLDRIQKR | KEEVAAKEQE | LEVKISQAKC | ICPERIEVSR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TARSLDTEIN | RLREKINSEE | VLHGNREEII | KQYHEAKERY | QDVEGKVKHL | KRFIKLLDEI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MAQRYKSYQQ | FRRCLTFRCK | IYFDSLLSQR | AYSGKINFDH | KNETLSITVQ | PGEGNKAALS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DMKCLSGGER | SFSTVCFILS | LWSIAESPFR | CLDEFDVYMD | MVNRRISMDM | MLSMADSQRF |
| 1090 | 1100 | 1110 | 1120 | ||
| RQFILLTPQN | MSSLPSTSLV | RILRMKDPER | GQTTLPFQPL | NQEAEDEE |