Q6P832

PR
Gene name
gatm
Protein name
Glycine amidinotransferase, mitochondrial
Names
L-arginine:glycine amidinotransferase, Transamidinase
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:394568
EC number
2.1.4.1: Amidinotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P832

Entry ID Method Resolution Chain Position Source
AF-Q6P832-F1 Predicted AlphaFoldDB

No variants for Q6P832

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P832

No associated diseases with Q6P832

No regional properties for Q6P832

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6P832

Functions

Description
EC Number 2.1.4.1 Amidinotransferases
Subcellular Localization
  • Mitochondrion inner membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor.
glycine amidinotransferase activity Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.

1 GO annotations of biological process

Name Definition
creatine biosynthetic process The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9I9K9 GATM Glycine amidinotransferase, mitochondrial Gallus gallus (Chicken) PR
P50440 GATM Glycine amidinotransferase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MLRVRCVRGG SRGAEAVHYI GSMLRKGFVG WVQRSFQSTQ AAAVSEKPCA ADEKVSDTAV
70 80 90 100 110 120
QECPVCSYNE WDPLEEVIVG RPENANVPPF SVEVKANTYE KYWPFYQKHG GQSFPVEHVK
130 140 150 160 170 180
KATEEIEEMC NVLRHEGVVV QRPEVIDWSV KYKTPDFEST GMYAAMPRDI LLVVGNEIIE
190 200 210 220 230 240
APMAWRARFF EYRAYRPLIK DYFRRGAKWT TAPKPTMADE LYDQDYPIRT VEDRHKLAAM
250 260 270 280 290 300
GKFVTTEFEP CFDAADFMRA GRDIFAQRSQ VTNYLGIEWM RRHLAPDYKV HIISFKDPNP
310 320 330 340 350 360
MHIDATFNII GPGLVLSNPD RPCHQIELFK KAGWTVVTPP IPLIPDNHPL WMSSKWLSMN
370 380 390 400 410 420
VLMLDEKRVM VDANETSIQK MFEKLGISTI KVNIRHANSL GGGFHCWTCD IRRRGTLQSY
FS