Q6P816
Gene name |
ykt6 |
Protein name |
Synaptobrevin homolog YKT6 |
Names |
EC 2.3.1.- |
Species |
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) |
KEGG Pathway |
xtr:394619 |
EC number |
|
Protein Class |
REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR (PTHR30204) |
Descriptions
SkgA belongs to the TipA class of transcription factors, which constitutes minimal autoregulated multidrug resistance (MDR) against diverse antibiotics. Upon binding of antibiotics to the TipAS domain within SkgA, SkgA is able to induce transcription of genes involved in multidrug resistance such as efflux pumps and antibiotics sequester proteins. The autoinhibition mechanism involves the a6–a7 region of the TipAS domain, which, in the unliganded state, interacts with the DNA-binding domain to stabilize the dimeric interface and hinder promoter DNA binding. This interaction prevents transcriptional activation by sterically blocking DNA access to the DNA-binding domain.
Autoinhibitory domains (AIDs)
Target domain |
138-198 (v-SNARE coiled-coil homology) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P816
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P816-F1 | Predicted | AlphaFoldDB |
No variants for Q6P816
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6P816 | |||||
No associated diseases with Q6P816
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR30204 | REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR |
| PANTHER Subfamily | PTHR30204:SF90 | HTH-TYPE TRANSCRIPTIONAL ACTIVATOR TIPA |
| PANTHER Protein Class |
helix-turn-helix transcription factor
winged helix/forkhead transcription factor |
|
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36015 | YKT6 | Synaptobrevin homolog YKT6 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q3T000 | YKT6 | Synaptobrevin homolog YKT6 | Bos taurus (Bovine) | SS |
| O15498 | YKT6 | Synaptobrevin homolog YKT6 | Homo sapiens (Human) | SS |
| Q9CQW1 | Ykt6 | Synaptobrevin homolog YKT6 | Mus musculus (Mouse) | SS |
| Q5EGY4 | Ykt6 | Synaptobrevin homolog YKT6 | Rattus norvegicus (Rat) | EV |
| Q9LVM9 | YKT62 | VAMP-like protein YKT62 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZRD6 | YKT61 | VAMP-like protein YKT61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7ZUN8 | ykt6 | Synaptobrevin homolog YKT6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVYTVKQMA | RLSGVSVRAL | HHYDAIGLLK | PRAVGANGYR | YYDRQDLLRL | QQILFHRALE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPLKDIQAAL | DQPGFDLAAA | LRAQRERLAA | QAERYARLVD | VVDRTLADLE | GDETMDDKHL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FEGFDPEKQA | RHEAWLVEHY | GDEATRRIAD | AKAGMKSWGK | KDWSQFQEEA | KAIEHDLAKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTQGLPVDSA | PVTAIMRRHW | AWVGRSWNRE | PTPDAFAGLG | HLYQANPEFT | ARYEAIAPGL |
| 250 | |||||
| TEYFSEAMRA | FARGR |