Q6P7W2
Gene name |
Shkbp1 (Sb1) |
Protein name |
SH3KBP1-binding protein 1 |
Names |
SETA-binding protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192192 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P7W2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P7W2-F1 | Predicted | AlphaFoldDB |
26 variants for Q6P7W2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1132976873 | 15 | G>E | No | EVA | |
| rs3388892792 | 57 | K>N | No | EVA | |
| rs3388892321 | 81 | T>I | No | EVA | |
| rs3388897265 | 87 | R>T | No | EVA | |
| rs3388880927 | 106 | L>V | No | EVA | |
| rs3388865813 | 170 | N>I | No | EVA | |
| rs3397296883 | 223 | S>A | No | EVA | |
| rs3397296887 | 227 | L>I | No | EVA | |
| rs3397760548 | 229 | F>C | No | EVA | |
| rs3397695683 | 229 | F>I | No | EVA | |
| rs3388887504 | 230 | S>Y | No | EVA | |
| rs3388893805 | 241 | L>P | No | EVA | |
| rs3388880971 | 269 | L>M | No | EVA | |
| rs3388893810 | 342 | S>G | No | EVA | |
| rs3388865784 | 350 | D>Y | No | EVA | |
| rs247923566 | 390 | D>N | No | EVA | |
| rs3388895083 | 408 | V>A | No | EVA | |
| rs3411152946 | 446 | V>E | No | EVA | |
| rs3397748313 | 481 | A>G | No | EVA | |
| rs3388888880 | 511 | Q>P | No | EVA | |
| rs3388897232 | 522 | V>E | No | EVA | |
| rs3388892317 | 595 | E>* | No | EVA | |
| rs49612358 | 612 | S>A | No | EVA | |
| rs3388882931 | 676 | W>S | No | EVA | |
| rs3388884817 | 685 | S>F | No | EVA | |
| rs3388895122 | 705 | F>E | No | EVA |
No associated diseases with Q6P7W2
5 regional properties for Q6P7W2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BTB/POZ domain | 19 - 119 | IPR000210 |
| repeat | WD40 repeat | 277 - 313 | IPR001680-1 |
| repeat | WD40 repeat | 419 - 457 | IPR001680-2 |
| repeat | WD40 repeat | 527 - 577 | IPR001680-3 |
| domain | Potassium channel tetramerisation-type BTB domain | 21 - 106 | IPR003131 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of epidermal growth factor receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVATTAVEG | VPSRGAPGEV | IHLNVGGKRF | STSRQTLTWI | PDSFFSSLLS | GRISTLKDET |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAIFIDRDPT | VFAPILNFLR | TKELDPRGVH | GSSLLHEAQF | YGLTPLVRRL | QVREELDRSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGNVLFNGYL | PPPVFPVKRR | NRHSLVGPQQ | IGGRPAPVRR | SNTMPPNLGN | AGLLGRMLDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RAPPSPSGQP | EEPGMVRLVC | GHHNWIAVAY | THFLVCYRLK | EASGWQLAFS | SPRLDWPIER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LALAARVLGG | APGEHDKMVA | AATGSEILLW | ALQAQGGGSE | IGVFHLGVPV | EALFFVGNQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IATSHTGRIG | VWNAVTKHWQ | VQEVQPITSY | DAAGSFLLLG | CSNGSIYYVD | VQKFPLRMKD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NDLLVSELYR | DPAEDGVTAL | SVYLTPKTSD | SGNWIEIAYG | TSSGVVRVIV | QHPETVGSGP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLFQTFSVHR | SPVTKIMLSE | KHLISVCADN | NHVRTWSVTR | FRGMISTQPG | STPLASFKIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALESVDGLGG | CSAGNDIGPY | GERDDQQVFI | QKVVPNASQL | FVRLSSTGQR | VCSVRSVDGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PTTAFTVLEC | EGSRRLGSRP | RRYLLTGQAN | GSLAMWDLTT | AMDGLGQTPA | GGLTEEELMD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLEQCELSPL | ASSRGSFPSP | SPRTSLTSLH | SASSNTSLYG | PRGSPSPPQA | EARRRGAGSF |
| 670 | 680 | 690 | 700 | ||
| VDRCQELARG | APELRWPPTP | APRPSTSLGN | PLTALKKTLN | ETSF |