Q6P6P7

PR
Gene name
Parp6
Protein name
Protein mono-ADP-ribosyltransferase PARP6
Names
ADP-ribosyltransferase diphtheria toxin-like 17, ARTD17, Poly [ADP-ribose] polymerase 6, PARP-6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67287
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

496-573 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P6P7

Entry ID Method Resolution Chain Position Source
AF-Q6P6P7-F1 Predicted AlphaFoldDB

No variants for Q6P6P7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P6P7

No associated diseases with Q6P6P7

1 regional properties for Q6P6P7

Type Name Position InterPro Accession
domain Poly(ADP-ribose) polymerase, catalytic domain 394 - 620 IPR012317

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
NAD+ ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
NAD+- protein-aspartate ADP-ribosyltransferase activity Catalysis of the reaction: L-aspartyl- + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-
NAD+- protein-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: L-cysteinyl- + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-
NAD+-protein ADP-ribosyltransferase activity Catalysis of the reaction: amino acyl- + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-

4 GO annotations of biological process

Name Definition
positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
protein ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids.
protein auto-ADP-ribosylation The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
protein mono-ADP-ribosylation The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N3A8 PARP8 Protein mono-ADP-ribosyltransferase PARP8 Homo sapiens (Human) PR
10 20 30 40 50 60
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE
70 80 90 100 110 120
YGTIDDVDLD LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN
130 140 150 160 170 180
KEGFGLGLQL KKILCMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI
190 200 210 220 230 240
PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH
250 260 270 280 290 300
VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350 360
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLQVA MCRAALESPR KSIIFEPYPS
370 380 390 400 410 420
VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW
430 440 450 460 470 480
IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW
490 500 510 520 530 540
HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN
550 560 570 580 590 600
RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620
GQVGDANINT QDPKIQKEIM RVIGTQVYTN