Q6P4S2

PR
Gene name
inpp5d (ship, ship1)
Protein name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Names
Inositol polyphosphate-5-phosphatase D, Phosphatidylinositol-4,5-bisphosphate 5-phosphatase, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399051
EC number
3.1.3.36: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

851-1010 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P4S2

Entry ID Method Resolution Chain Position Source
AF-Q6P4S2-F1 Predicted AlphaFoldDB

No variants for Q6P4S2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P4S2

No associated diseases with Q6P4S2

3 regional properties for Q6P4S2

Type Name Position InterPro Accession
domain Inositol polyphosphate-related phosphatase 396 - 712 IPR000300
domain SH2 domain 3 - 101 IPR000980
domain Endonuclease/exonuclease/phosphatase 404 - 695 IPR005135

Functions

Description
EC Number 3.1.3.36 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Membrane raft
  • Cytoplasm, cytoskeleton
  • Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
inositol-1,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.
inositol-polyphosphate 5-phosphatase activity Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate.
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

2 GO annotations of biological process

Name Definition
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYGWYHGNI TRSKAEDLLS QAGKDGSYLV RDSESVCRAY ALCVLNQNCV HTYRILQNAE
70 80 90 100 110 120
HQLSVQASEG VPMRFFTNLV ELIEFYRREN VGLVTHLQYP IEKEEEGPEE PDEEQEPAPP
130 140 150 160 170 180
NVPPRNFAFT PPSETKECQT AIERAPAANA SLLLSETLLQ RFQDTDSRCI PEEHLQAICD
190 200 210 220 230 240
YFSLHIVSDC DMVRTGSQTL PQFKKLLMTL CTGLHRELTR TLPTLESLQV AIDPQLSPGF
250 260 270 280 290 300
KQRSPLPGDS ATNNMVNKLT HLTSMVSNLE EKVKTVLMEG AAVKHRRSLI PPIIFEVKAD
310 320 330 340 350 360
SIGISQKTHL KVDVETGKLI IKKSKDGPDD KFYPSKKILQ LIKSQKFPHK LVIVLETEKE
370 380 390 400 410 420
KTQRKEYVFA DSKKREGFCQ LLQQMKNKHS GQSEPDMLSI FIGTWNMGDA PPPKNITPWF
430 440 450 460 470 480
QCKGQGKTRD DTADYIEHDI YVIGTQEDPL SEKEWTDTLI HSLREITSVE YKVITTQTLW
490 500 510 520 530 540
NIRIVVLAKP EHAHRISHVC TNSVKTGIAN TLGNKGAVGA SFMFNGTSFG FINSHLTSGS
550 560 570 580 590 600
EKKLRRNQNY FNILRFLVLG DKKLSPFNFT HRFNHLFWLG DLNYRLQLPN TEAENIIQKI
610 620 630 640 650 660
KQQQHQELLP HDQLNLERRE SLIFFQFHEE EITFPPTYRY ERGSRERYCY TKQKATGIKY
670 680 690 700 710 720
NLPSWCDRIL WKSYPQMHIL CQSYGCTDDI TTSDHSPVFG TFQVGVTSQF VSKNNPGDSG
730 740 750 760 770 780
DLEAQGHIEL MNCKATLYTK SHTKFYIEFH SPCLENMVKS SEAEDQEGNN GTLVVKFGVL
790 800 810 820 830 840
PKLTPIISDL EYLLDQHLLI CIKSSDTDES YGEGCIALRK EDTEQQFPFC TILTHHGEET
850 860 870 880 890 900
GLFCGEICLP ASGGKQREKL YDFVKIEKDE TVAQKQLKHP YSQSMEQSRI MKSISEKSAM
910 920 930 940 950 960
IARMRAAPET QNSMDHTASV AAISSQAKQS PPTTPPGFRG SEPRQKPGSP VQGRGDTPIT
970 980 990 1000 1010
SPPRTTLSTQ KFSHSNTNRT APAARPQDSL QITVPSDPHE MVDNPLYGPV NNTLYPPTA