AiPD: Autoinhibited Protein Database

Gene name	Thap4
Protein name	Peroxynitrite isomerase THAP4
Names	Ferric nitrobindin, Nb(III), THAP domain-containing protein 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:67026
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

201-270 (Predicted disordered autoinhibitory region) PR

201-270 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6P3Z3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3390257160	25	H>L	No	EVA
rs3388489894	41	A>T	No	EVA
rs3388489591	43	Q>R	No	EVA
rs3388492768	53	S>T	No	EVA
rs3388492941	113	S>N	No	EVA
rs3390330861	117	G>V	No	EVA
rs3388491666	123	S>T	No	EVA
rs32038373	145	P>L	No	EVA
rs3390325601	152	K>*	No	EVA
rs3388489903	156	G>C	No	EVA
rs262170035	181	G>A	No	EVA
rs3388491554	296	V>A	No	EVA
rs3390338891	428	P>T	No	EVA
rs3388490448	446	V>L	No	EVA
rs259452041	455	M>V	No	EVA
rs3388491512	467	T>I	No	EVA
rs3388490383	496	G>V	No	EVA
rs3388491640	503	G>V	No	EVA
rs3388491540	506	N>D	No	EVA
rs3388492029	534	K>T	No	EVA
rs3390256218	557	T>I	No	EVA
rs3390344409	559	H>N	No	EVA

Type	Name	Position	InterPro Accession
domain	THAP-type zinc finger	1 - 91	IPR006612
domain	THAP4-like, heme-binding beta-barrel domain	414 - 567	IPR014878

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Localizes mainly in the cytoplasm and partially in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
nitric oxide binding	Binding to nitric oxide (NO).
peroxynitrite isomerase activity	Catalysis of the reaction: peroxynitrite = nitrate.

Name	Definition
nitrate metabolic process	The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid.
tyrosine metabolic process	The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q642B6	Thap4	Peroxynitrite isomerase THAP4	Rattus norvegicus (Rat)	PR