Q6P3L0

PR
Gene name
mvp
Protein name
Major vault protein
Names
MVP
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:373081
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

318-397 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P3L0

Entry ID Method Resolution Chain Position Source
AF-Q6P3L0-F1 Predicted AlphaFoldDB

No variants for Q6P3L0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P3L0

No associated diseases with Q6P3L0

17 regional properties for Q6P3L0

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 677 - 706 IPR000048
repeat Major vault protein, N-terminal 60 - 120 IPR002499-1
repeat Major vault protein, N-terminal 121 - 173 IPR002499-2
repeat Major vault protein, N-terminal 174 - 226 IPR002499-3
repeat Major vault protein, N-terminal 227 - 281 IPR002499-4
repeat Major vault protein, N-terminal 283 - 331 IPR002499-5
repeat Major vault protein, N-terminal 332 - 400 IPR002499-6
repeat Major vault protein, N-terminal 401 - 453 IPR002499-7
domain Major vault protein, shoulder domain 523 - 674 IPR021870
domain Major vault protein repeat domain 3 471 - 532 IPR040989
domain Major vault protein repeat domain 2 54 - 113 IPR041134-1
domain Major vault protein repeat domain 2 278 - 324 IPR041134-2
domain Major vault protein repeat domain 4 396 - 455 IPR041136
domain Major vault protein repeat domain 117 - 158 IPR041139-1
domain Major vault protein repeat domain 170 - 210 IPR041139-2
domain Major vault protein repeat domain 224 - 265 IPR041139-3
domain Major vault protein repeat domain 328 - 385 IPR041139-4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
neuron projection regeneration The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14764 MVP Major vault protein Homo sapiens (Human) PR
10 20 30 40 50 60
MDADHLLGAS IIRIPPHHYI HVLDQNTNIA RVEIGPLTYI RQDNERVLFA PVRMMMVPPR
70 80 90 100 110 120
HYCVVLNPAV RDDEGQVQFD GSGQVKLRHA DLEIRLAQDP FPLYPGEEIQ KDVTPLQIVY
130 140 150 160 170 180
PDTALRLQAL LDFEEEGGEK RVAGDEWLFE GPGTYIPRKE VTVLEVIKAT VIRENQAIRL
190 200 210 220 230 240
RARKEGLDRS GVQRVTGEEW QVSKVGAYLP GAHEEVVDIV SAFILTDKKA LHVRAIRPFR
250 260 270 280 290 300
DAGGRDRRTG EEWLVTVADR EAHIPSVAEE VVGVVDVTTL NSRQYCVIMD PVGADGKPQL
310 320 330 340 350 360
GQKRVVKGER SFFLMPGEHL ENGIQDVYVL SEEEGLVLRA VEAFIDTQGD EAEEEERESR
370 380 390 400 410 420
AKKRGVQRRP GDRWMLRGPI EYVPPATVEV LLTRTAIPLD ENEGIYVRDI KTGKVRAVIG
430 440 450 460 470 480
QTYMLTQDEE LWEKELPANV ESLLAQSRDP LADRSDRGRS FGQAERDKTR VVSYRIPHNA
490 500 510 520 530 540
TVQVYDYREK KARVMFGPEM VMLGPDEQFT VLSLSGDKPK RPNVIKTICL LLGPDFCTDI
550 560 570 580 590 600
ITIETADHAR LQLQLSYNWH FDLKQPADAA QAAALFSVPD FVGDACKAIA SRIRGAVASV
610 620 630 640 650 660
QFDDFHKNSN RIICSAVFGF DEKLAVRSSL RFGQNGLVIS SVDIQSVEPV DQRTRDALQK
670 680 690 700 710 720
SVQLAIEITT NSQEAAARHE AERLEQEARG RLERQKITDQ AEAEKARKEL LELEAQSAAV
730 740 750 760 770 780
ESTGAAKAEA QSRAEAARIQ GEAAVEEAKL KAEAQKIEAD SELARLCKAR EQELNYKKQI
790 800 810 820 830 840
DHLEVEKQQK LADIESQRFK HLMDNLGTET LKEMARAGPE LQVKLLQSLG LKSTLITDGS
850 860
SPINLFTTAN GLLGSLQGKD KDE