Q6NZQ0

PR
Gene name
Cfap119
Protein name
Cilia- and flagella-associated protein 119
Names
Coiled-coil domain-containing protein 189
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:233899
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NZQ0

Entry ID Method Resolution Chain Position Source
AF-Q6NZQ0-F1 Predicted AlphaFoldDB

30 variants for Q6NZQ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388934419 15 Q>E No EVA
rs33155843 32 P>S No EVA
rs244774835 35 V>M No EVA
rs3388923916 40 I>V No EVA
rs3388945250 43 G>V No EVA
rs222240529 58 P>L No EVA
rs3388907486 58 P>S No EVA
rs3398289722 90 M>V No EVA
rs3398635337 93 L>M No EVA
rs3398759604 109 L>I No EVA
rs3388907535 117 Q>* No EVA
rs3388952362 118 S>R No EVA
rs3388907518 128 F>L No EVA
rs3388923914 133 I>F No EVA
rs3388956861 135 C>Y No EVA
rs3388952437 151 M>I No EVA
rs3388945286 159 C>Y No EVA
rs3388952412 195 E>A No EVA
rs3388953130 245 K>R No EVA
rs3388938313 249 E>* No EVA
rs3388922292 274 P>S No EVA
rs3388930069 282 T>S No EVA
rs3388945612 283 Y>* No EVA
rs3388922287 283 Y>N No EVA
rs3398388863 293 R>S No EVA
rs3388938331 305 E>* No EVA
rs3388953123 308 E>G No EVA
rs257072611 319 Q>R No EVA
rs3388934440 324 P>S No EVA
rs3388952406 328 G>A No EVA

No associated diseases with Q6NZQ0

No regional properties for Q6NZQ0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6NZQ0

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium, flagellum
  • Cytoplasmic vesicle, secretory vesicle, acrosome
  • Cytoplasm
  • In elongated spermatids, enriched in the principal piece of flagella where it is peri-axonemal
  • Disappears from sperm heads upon acrosome reaction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
sperm principal piece The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A4V9 CFAP119 Cilia- and flagella-associated protein 119 Homo sapiens (Human) PR
10 20 30 40 50 60
MITPSSSQSL GMKVQMESEQ SPKLQEELDR SPSSVDGSAI RNGTDMQTES PAEATSSPVE
70 80 90 100 110 120
VAEDPGANLF PPPLPQPRIC MWKYLDIHSM HRLEKAATVE KMREVLAELL ELGFPEQSLR
130 140 150 160 170 180
DAIILDLFSH ALIFCRQQGF SPEQTSAACA MLQDLHKACV ATPLGNVEEC YRYFTSVLFC
190 200 210 220 230 240
HGIRRPPFSI DLFKEEQLLA LADYVVNTYF RHFKLYKYVF TPQVRLDLSL TYTGLQPLTL
250 260 270 280 290 300
WPEEKENEEM MVVEQVATPQ EEEPETVTEP EQQPSEVCIL QTYIKSQLSK ELRQLQQLVE
310 320 330
ERLKESEERL SSKLAALEQP FQTPPSKGKT KTK