Q6NUM6
PR
Gene name |
TYW1B (RSAFD2) |
Protein name |
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B |
Names |
Radical S-adenosyl methionine and flavodoxin domain-containing protein 2, tRNA wybutosine-synthesizing protein 1 homolog B |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:441250 |
EC number |
4.1.3.44: Oxo-acid-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NUM6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NUM6-F1 | Predicted | AlphaFoldDB |
606 variants for Q6NUM6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1554481550 CA367712874 |
2 | D>E | No |
ClinGen gnomAD |
|
|
rs782579642 CA4283018 |
2 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA4283017 rs782579642 |
2 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA4282991 rs376108043 |
5 | A>V | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
rs782109332 CA4282989 |
7 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA4282988 rs73131518 |
7 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282990 rs782109332 |
7 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA160013810 rs754323800 |
8 | W>* | No |
ClinGen gnomAD |
|
|
CA367712844 rs1554481543 |
8 | W>R | No |
ClinGen TOPMed |
|
|
CA367712827 rs1554481540 |
10 | L>F | No |
ClinGen gnomAD |
|
|
CA4282984 rs782367455 |
11 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1554481532 CA367712816 |
12 | S>A | No |
ClinGen gnomAD |
|
|
CA4282981 rs781819204 |
14 | L>G | No |
ClinGen ExAC |
|
|
CA4282979 rs536185667 |
15 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282977 rs782292598 |
16 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs782384362 CA4282978 |
16 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA4282972 rs782322103 |
19 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA4282971 rs782184025 |
21 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA367712752 rs1554481517 |
22 | F>L | No |
ClinGen gnomAD |
|
|
CA367712751 rs1554481517 |
22 | F>V | No |
ClinGen gnomAD |
|
|
rs782601748 CA4282970 |
23 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
rs782520278 CA4282969 |
24 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367712728 rs1183161997 |
25 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
CA4282968 rs142535243 |
27 | G>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282967 rs142535243 |
27 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367712716 rs1554481510 |
27 | G>V | No |
ClinGen gnomAD |
|
|
CA4282966 rs782540464 |
28 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA367712639 rs1554481504 |
38 | V>G | No |
ClinGen gnomAD |
|
|
rs781802582 CA4282965 |
38 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs547214941 CA4282964 |
40 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs374751967 CA4282963 |
41 | V>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367712623 rs1364128010 |
41 | V>L | No |
ClinGen TOPMed |
|
|
rs201638072 CA4282961 |
43 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs782122344 CA4282960 |
45 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782001168 CA4282934 |
46 | G>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372230414 CA4282933 |
46 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282932 rs184391894 |
49 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1554479255 CA367711899 |
49 | T>I | No |
ClinGen gnomAD |
|
|
CA4282931 rs782015914 |
51 | L>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 52 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367711830 rs1185129844 |
55 | V>I | No |
ClinGen TOPMed |
|
|
CA367711814 rs556042271 |
56 | T>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282930 rs556042271 |
56 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781960217 CA4282928 |
57 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554479242 CA367711786 |
59 | D>Y | No |
ClinGen gnomAD |
|
|
rs113109533 CA4282923 |
62 | V>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282924 rs782561173 |
62 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA4282921 rs551443078 |
63 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282920 rs781842289 |
65 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1414773338 CA367711712 |
65 | I>V | No |
ClinGen TOPMed |
|
|
rs782723471 CA4282919 |
66 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs533050338 CA4282918 |
67 | L>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367711677 rs533050338 |
67 | L>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1554479229 CA367711682 |
67 | L>V | No |
ClinGen gnomAD |
|
|
CA160010099 rs777397387 |
69 | E>* | No |
ClinGen Ensembl |
|
|
CA4282917 rs781901924 |
70 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282916 rs782796093 |
72 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs782062822 CA4282915 |
73 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA4282914 rs781782971 |
75 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1348889719 CA367711535 |
77 | I>T | No |
ClinGen TOPMed |
|
|
CA4282913 rs782743220 |
79 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367711394 rs1211738519 |
80 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs376640324 CA4282896 |
82 | S>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs782119090 CA4282895 |
83 | K>* | No |
ClinGen ExAC gnomAD |
|
|
CA367711378 rs782119090 |
83 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1554477970 CA367711371 |
84 | N>D | No |
ClinGen gnomAD |
|
|
CA367711360 rs1187396264 |
85 | V>A | No |
ClinGen TOPMed |
|
|
rs1554477967 CA367711353 |
86 | C>S | No |
ClinGen gnomAD |
|
|
CA367711344 rs1554477962 |
88 | F>I | No |
ClinGen gnomAD |
|
|
CA4282893 rs781906069 |
88 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA160008414 rs200973019 |
88 | F>S | No |
ClinGen TOPMed |
|
|
rs1554477959 CA367711337 |
89 | L>V | No |
ClinGen gnomAD |
|
|
CA4282892 rs373659186 |
91 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1563102352 CA915483983 |
93 | Y>* | No |
ClinGen Ensembl |
|
|
rs1554477950 CA367711307 |
94 | T>A | No |
ClinGen gnomAD |
|
|
CA367711298 rs1324394715 |
95 | D>G | No |
ClinGen TOPMed |
|
|
rs782414363 CA4282886 |
96 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs782007195 CA4282887 |
96 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782414363 CA367711291 |
96 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782270162 CA367711281 |
98 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
rs782270162 CA4282885 |
98 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs782574708 CA4282884 |
99 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367711276 rs1554477934 |
99 | T>I | No |
ClinGen gnomAD |
|
|
rs782217657 CA4282882 |
100 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372002786 CA4282880 |
101 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372002786 CA4282879 |
101 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372002786 CA4282881 |
101 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367711243 rs782535675 |
104 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282877 rs782535675 |
104 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282876 rs549041845 |
107 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs782691551 CA4282875 |
108 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs782496911 CA4282874 |
108 | W>C | No |
ClinGen ExAC gnomAD |
|
|
CA4282872 rs782780891 |
109 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs781826720 CA4282873 |
109 | L>I | No |
ClinGen ExAC |
|
|
CA367711186 rs1259016778 |
112 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1259016778 CA367711185 |
112 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA367711176 rs1554477915 |
114 | I>F | No |
ClinGen gnomAD |
|
|
rs782017364 CA4282870 |
114 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282869 rs782726565 |
117 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282868 rs782046046 |
117 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA4282867 rs527369175 |
118 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367711144 rs1163259955 |
119 | G>C | No |
ClinGen TOPMed |
|
|
rs1554477901 CA367711139 |
120 | K>E | No |
ClinGen gnomAD |
|
|
CA367711109 rs1554477897 |
124 | K>R | No |
ClinGen gnomAD |
|
|
CA367711110 rs1554477897 |
124 | K>T | No |
ClinGen gnomAD |
|
|
CA4282865 rs782260099 |
125 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282863 rs112022599 |
126 | M>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282864 rs781978020 |
126 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA367711099 rs1554477895 |
126 | M>V | No |
ClinGen gnomAD |
|
|
rs782284907 CA367711083 |
128 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA4282862 rs782284907 |
128 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA367711085 rs1158540242 |
128 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA367711084 rs1158540242 |
128 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA367711079 rs1554477891 |
129 | A>T | No |
ClinGen gnomAD |
|
|
rs116226916 CA4282861 |
129 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367711072 rs1586001821 |
130 | V>L | No |
ClinGen Ensembl |
|
|
CA367711056 rs533168112 |
132 | G>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs533168112 CA4282858 |
132 | G>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782515973 CA4282857 |
133 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1586001811 CA367711048 |
134 | G>E | No |
ClinGen Ensembl |
|
|
CA160008129 rs759983441 |
135 | N>D | No |
ClinGen TOPMed |
|
|
rs782793123 CA4282855 |
136 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs782453388 CA4282854 |
138 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs550856466 CA4282852 |
139 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1554477867 CA367711014 |
140 | S>G | No |
ClinGen gnomAD |
|
|
CA4282851 rs782073009 |
140 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1554477865 CA367711003 |
141 | H>L | No |
ClinGen gnomAD |
|
|
rs782771269 CA4282849 |
143 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
TCGA novel rs529219067 CA4282848 |
144 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
rs376698211 CA160023596 |
145 | V>A | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA4282824 rs146105977 |
145 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781801354 CA4282823 |
146 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282822 rs782231454 |
146 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA4282821 rs535869985 |
147 | K>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA367712563 rs1404128571 |
148 | N>T | No |
ClinGen TOPMed |
|
|
CA367712548 rs1554477013 |
150 | D>G | No |
ClinGen gnomAD |
|
|
CA367712529 rs1342258073 |
152 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
rs782237031 CA4282819 |
153 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554477003 CA367712521 |
154 | W>R | No |
ClinGen gnomAD |
|
|
rs782550663 CA4282817 |
156 | L>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782550663 CA4282818 |
156 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282815 rs535173722 |
158 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282814 rs370126013 |
159 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282813 rs201902056 |
160 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282812 rs375458552 |
160 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201902056 CA367712482 |
160 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1195113834 CA367712472 CA367712470 |
162 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
CA4282811 rs531094097 |
164 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs531094097 CA367712455 |
164 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781907760 CA4282810 |
164 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs563662474 CA160023518 CA4282809 |
165 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367712447 rs1554476970 |
166 | E>Q | No |
ClinGen gnomAD |
|
|
CA4282807 rs781966416 |
167 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs782049001 CA4282808 |
167 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA4282804 rs547750453 |
168 | D>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs782126507 CA4282805 |
168 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs547750453 CA367712433 |
168 | D>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA367712435 rs782126507 |
168 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282802 rs372474886 |
170 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs367926389 CA4282800 |
171 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1284319524 CA367712406 |
172 | V>G | No |
ClinGen TOPMed |
|
|
CA4282799 rs782232724 |
172 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282798 rs782609925 |
173 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA4282797 rs782247210 |
176 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782550288 CA4282794 |
177 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs782687265 CA4282795 |
177 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs782758806 CA4282792 |
179 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs376927077 CA4282793 |
179 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1290035215 CA367712362 |
179 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1585998972 CA367712346 |
181 | A>G | No |
ClinGen Ensembl |
|
|
CA4282791 rs782463070 |
182 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282790 rs371606288 |
182 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1554476928 CA367712338 |
183 | F>I | No |
ClinGen gnomAD |
|
| TCGA novel | 183 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4282789 rs782754416 |
185 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367712301 rs1238185446 |
188 | T>P | No |
ClinGen TOPMed |
|
|
CA4282787 rs782015691 |
189 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1585998915 CA367712286 |
190 | F>V | No |
ClinGen Ensembl |
|
|
CA4282785 rs782055508 |
191 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782055508 CA4282784 |
191 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781973351 CA4282783 |
192 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282782 rs782348774 |
193 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1554476907 CA367712260 |
194 | L>P | No |
ClinGen gnomAD |
|
|
CA367712258 rs1381875309 |
195 | Q>* | No |
ClinGen TOPMed |
|
| TCGA novel | 196 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1440103838 CA367712236 |
198 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA367712234 rs1554476901 |
198 | Q>R | No |
ClinGen gnomAD |
|
|
CA367712230 rs1554476899 |
199 | K>Q | No |
ClinGen gnomAD |
|
|
rs782423058 CA4282779 |
202 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367712200 rs1554476890 |
203 | K>* | No |
ClinGen gnomAD |
|
|
CA367712198 rs1416150484 |
203 | K>R | No |
ClinGen TOPMed |
|
|
CA367712181 rs868942800 |
205 | S>F | No |
ClinGen Ensembl |
|
|
CA160023283 rs367840847 |
208 | G>D | No |
ClinGen ESP TOPMed |
|
|
CA367712165 rs1449924689 |
208 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1379510545 CA367712157 |
209 | H>R | No |
ClinGen TOPMed |
|
|
CA367712144 rs1240174559 |
211 | K>E | No |
ClinGen TOPMed |
|
|
rs782476993 CA4282776 |
211 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs1279392938 CA367712132 |
212 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1349149703 CA367712127 |
213 | G>D | No |
ClinGen TOPMed |
|
|
rs782208674 CA4282775 |
215 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282773 rs782505041 |
217 | S>C | No |
ClinGen ExAC |
|
|
rs781896593 CA4282772 |
218 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1460939630 CA367712081 |
220 | H>N | No |
ClinGen TOPMed |
|
|
CA367712077 rs1554476875 |
220 | H>R | No |
ClinGen gnomAD |
|
|
CA367712070 rs1201954713 |
221 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1201954713 CA367712071 |
221 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA4282770 rs782451575 |
221 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs781799237 CA4282769 |
224 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1554476866 CA367712034 |
226 | E>D | No |
ClinGen gnomAD |
|
|
rs1240296337 CA367712040 |
226 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1458414756 CA367712028 |
227 | E>G | No |
ClinGen TOPMed |
|
|
CA4282768 rs782767076 |
228 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782086272 CA4282766 |
230 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs782009089 CA4282765 |
231 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367712006 rs782009089 |
231 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282764 rs782754152 |
232 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs782020340 CA4282762 |
233 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782331205 CA4282761 |
234 | E>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs782098315 CA4282760 |
234 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782331205 CA367711985 |
234 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs781947108 CA4282759 |
236 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs782240448 CA4282757 |
237 | H>L | No |
ClinGen ExAC gnomAD |
|
|
rs782240448 CA367711962 |
237 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA4282758 rs782393455 |
237 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs370976921 CA160023177 |
238 | R>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282756 rs370976921 |
238 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367711957 rs1390522161 |
238 | R>I | No |
ClinGen TOPMed |
|
|
rs782195388 CA4282754 |
240 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs1554476838 CA367711940 |
241 | K>E | No |
ClinGen gnomAD |
|
|
rs1554476837 CA367711936 |
241 | K>R | No |
ClinGen gnomAD |
|
|
CA4282737 rs782235887 |
242 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554476003 CA367711889 |
242 | E>K | No |
ClinGen gnomAD |
|
|
CA4282735 rs782394287 |
243 | E>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 243 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs570707296 CA4282734 |
244 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782533916 CA4282733 |
245 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282732 rs782533916 |
245 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782464500 CA4282729 |
247 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs782464500 CA367711818 |
247 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4282728 rs781870157 |
248 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA4282727 rs782757257 |
250 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA4282723 rs782044108 |
251 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782726333 CA4282724 |
251 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA4282725 rs781885537 |
251 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA4282722 rs537327533 |
252 | E>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1554475978 CA367711756 |
252 | E>K | No |
ClinGen gnomAD |
|
|
CA367711704 rs1554475968 |
256 | G>S | No |
ClinGen gnomAD |
|
|
CA367711664 rs782136476 |
259 | H>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367711660 rs1554475960 |
259 | H>R | No |
ClinGen gnomAD |
|
|
CA4282719 rs782136476 |
259 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781989509 CA4282718 |
261 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA4282716 rs782280364 |
265 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1278746526 CA367711560 |
267 | D>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1374506024 CA367711553 |
267 | D>E | No |
ClinGen TOPMed |
|
|
CA4282714 rs782314943 |
269 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367711509 rs1554475942 |
271 | L>V | No |
ClinGen gnomAD |
|
|
CA367711467 rs1304121394 |
275 | M>T | No |
ClinGen TOPMed |
|
|
CA367711462 rs1346490471 |
276 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs782497924 CA4282711 |
278 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1274665949 CA367711418 |
281 | E>D | No |
ClinGen TOPMed |
|
|
CA4282710 rs782288987 |
282 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs782379557 CA4282697 |
283 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA160014953 rs782685376 |
289 | E>K | No |
ClinGen gnomAD |
|
|
rs1296855631 CA367710890 |
293 | G>D | No |
ClinGen TOPMed |
|
|
rs201632568 CA4282691 |
295 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282690 rs782566996 |
297 | N>D | No |
ClinGen ExAC TOPMed |
|
|
CA367710850 rs1554470776 |
299 | G>R | No |
ClinGen gnomAD |
|
|
CA4282689 rs782485010 |
302 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA367710812 rs1554470770 |
304 | G>D | No |
ClinGen TOPMed |
|
|
CA4282688 rs782205473 |
304 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA367710792 rs1490570750 |
307 | R>K | No |
ClinGen TOPMed |
|
|
rs782661582 CA367710788 |
307 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282685 rs373122167 |
309 | M>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs572381996 CA4282684 |
310 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282683 rs782463490 |
311 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA367710765 rs1554470759 |
311 | T>S | No |
ClinGen gnomAD |
|
|
rs553900797 CA4282682 |
312 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA160014896 rs765223797 |
313 | A>D | No |
ClinGen gnomAD |
|
|
CA367710754 rs765223797 |
313 | A>G | No |
ClinGen gnomAD |
|
|
rs1166289096 CA367710750 |
314 | L>F | No |
ClinGen TOPMed |
|
|
CA4282681 rs539087501 |
315 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367710745 rs1554470748 |
315 | R>Q | No |
ClinGen gnomAD |
|
|
rs782125271 CA4282680 |
319 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554470734 CA367710702 |
321 | Q>H | No |
ClinGen gnomAD |
|
|
CA4282660 rs781881258 |
323 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1301335559 CA367710649 |
325 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs782700183 CA4282659 |
325 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1301335559 CA367710648 |
325 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs781841676 CA4282657 |
328 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1479513049 CA367710623 |
329 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1554463235 CA367710618 |
329 | S>R | No |
ClinGen gnomAD |
|
|
rs1211379015 CA367710600 |
332 | Q>* | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 332 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367710593 rs1554463225 |
333 | T>A | No |
ClinGen gnomAD |
|
|
rs781987940 CA367710580 |
335 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282654 rs781987940 |
335 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554463211 CA367710577 |
335 | I>T | No |
ClinGen gnomAD |
|
|
CA4282653 rs781987940 |
335 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554463202 CA367710572 |
336 | L>P | No |
ClinGen gnomAD |
|
|
CA4282652 rs782435864 |
337 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1585948851 CA367710556 |
338 | N>K | No |
ClinGen Ensembl |
|
|
rs1585948846 CA367710551 |
339 | E>A | No |
ClinGen Ensembl |
|
| TCGA novel | 339 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1449709589 CA367710542 |
340 | S>N | No |
ClinGen TOPMed |
|
|
CA4282651 rs782144257 |
342 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781946271 CA4282650 |
342 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367710514 rs1295642649 |
344 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA4282648 rs782237838 |
345 | E>K | No |
ClinGen ExAC |
|
|
rs1554463173 CA367710489 |
348 | P>A | No |
ClinGen gnomAD |
|
|
rs782604845 CA4282647 |
348 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782291559 CA4282644 |
350 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367710471 rs1367384635 |
351 | A>T | No |
ClinGen TOPMed |
|
|
rs782650215 CA4282643 |
351 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs781789516 CA4282641 |
353 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA367710453 rs782625699 |
354 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA4282640 rs782625699 |
354 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA160002854 rs781845199 |
355 | K>E | No |
ClinGen Ensembl |
|
|
rs1295175674 CA367710444 |
355 | K>T | No |
ClinGen TOPMed |
|
|
rs1246791651 CA367710434 |
356 | C>* | No |
ClinGen TOPMed gnomAD |
|
|
rs782461069 CA4282639 |
356 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367710425 rs1467978611 |
358 | F>L | No |
ClinGen TOPMed |
|
|
CA367710426 rs1467978611 |
358 | F>V | No |
ClinGen TOPMed |
|
|
rs1554463118 CA367710414 |
359 | C>* | No |
ClinGen gnomAD |
|
|
CA367710415 rs782767508 |
359 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781872590 CA367710417 |
359 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs781872590 CA4282638 |
359 | C>S | No |
ClinGen ExAC gnomAD |
|
|
CA4282637 rs782767508 |
359 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282635 rs781892655 |
360 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782708042 CA4282634 |
360 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781892655 CA4282636 |
360 | W>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282633 rs2687015 |
361 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367993582 rs781877106 |
362 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
CA4282616 rs782468726 |
362 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA160858833 rs781988434 |
363 | H>L | No |
ClinGen gnomAD |
|
|
CA4282614 rs782796977 |
363 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs781988434 CA160858834 |
363 | H>R | No |
ClinGen gnomAD |
|
|
CA367993572 rs1482974032 |
364 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1585935577 CA367993562 |
365 | N>I | No |
ClinGen Ensembl |
|
|
CA367993561 rs1554459278 |
365 | N>K | No |
ClinGen gnomAD |
|
|
CA367993564 rs1585935577 |
365 | N>T | No |
ClinGen Ensembl |
|
|
CA4282613 rs782145020 |
366 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1554459274 CA367993552 |
367 | V>L | No |
ClinGen gnomAD |
|
|
CA367993554 rs1554459274 |
367 | V>M | No |
ClinGen gnomAD |
|
|
CA367993541 rs1554459271 |
369 | T>P | No |
ClinGen gnomAD |
|
|
CA4282610 rs117110249 |
372 | L>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA918041537 rs386714630 |
372 | L>R | No |
ClinGen Ensembl |
|
|
rs117110249 CA160858830 |
372 | L>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs3015858 CA160858826 |
373 | W>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| rs1585935515 | 373 | W>G | No | Ensembl | |
| rs3015858 | 373 | W>L | No |
1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367993510 rs1554459261 CA367993509 |
374 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1554459258 CA367993505 |
375 | M>K | No |
ClinGen gnomAD |
|
|
CA4282606 rs181240185 |
376 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs541797116 CA4282607 |
376 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782493809 CA4282602 |
380 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782569173 CA4282603 |
380 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1373672981 CA367993430 |
385 | A>S | No |
ClinGen TOPMed |
|
|
rs1373672981 CA367993432 |
385 | A>T | No |
ClinGen TOPMed |
|
|
CA4282600 rs782218675 |
386 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA4282599 rs782645473 |
388 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs149581454 CA4282598 |
389 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367993396 rs868931549 |
390 | Q>* | No |
ClinGen Ensembl |
|
|
CA4282597 rs781879625 |
392 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 392 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4282596 rs782581740 |
395 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA367993359 rs782581740 |
395 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA4282595 rs531276126 |
396 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282594 rs781832946 |
397 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs146095374 CA367992626 |
398 | G>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367993338 rs1554459237 |
398 | G>R | No |
ClinGen gnomAD |
|
|
rs146095374 CA4282580 |
398 | G>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282578 rs199848825 |
400 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199848825 CA160858131 |
400 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA160858132 rs200621587 |
400 | P>T | No |
ClinGen Ensembl |
|
|
CA367992609 rs565333577 |
402 | V>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282575 rs565333577 |
402 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781887770 CA4282573 |
405 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA4282574 rs547030047 |
405 | E>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782046369 CA4282571 |
406 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782046369 CA367992584 |
406 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282570 rs781843856 |
406 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs532191787 CA4282569 |
412 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282568 rs532191787 |
412 | T>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782061374 CA4282565 |
416 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs782350607 CA4282563 |
418 | L>F | No |
ClinGen ExAC |
|
|
CA367992492 rs1218800867 |
419 | S>C | No |
ClinGen TOPMed |
|
|
rs782201165 CA4282562 |
420 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs782374967 CA4282560 |
421 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4282559 rs782293727 |
422 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs782663981 CA4282558 |
425 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA160858130 rs571257336 |
425 | I>V | No |
ClinGen 1000Genomes |
|
|
rs782450869 CA4282557 |
426 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA4282556 rs782610465 |
427 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367992437 rs1554455299 |
428 | P>L | No |
ClinGen gnomAD |
|
|
rs782483575 CA4282554 |
429 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs371891315 CA4282553 |
430 | I>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 432 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367992406 rs1244986859 |
433 | F>V | No |
ClinGen TOPMed |
|
|
CA4282551 rs782556917 |
438 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781800095 CA4282550 |
439 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA4282549 rs782698910 |
440 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA4282548 rs782091047 |
443 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA367992316 rs1422691044 |
446 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA4282545 rs782114238 |
447 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367992295 rs1391361575 |
449 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs782036102 CA4282544 |
449 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782407348 CA367992262 |
453 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA4282543 rs782407348 |
453 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA4282542 rs180988100 |
454 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 455 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 457 | R>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367991520 rs1375894253 |
457 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs782611861 CA4282514 |
458 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs782337617 CA4282513 |
458 | N>K | No |
ClinGen ExAC |
|
|
CA367991516 rs1585908805 |
458 | N>T | No |
ClinGen Ensembl |
|
|
rs782258231 CA4282512 |
459 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782541665 CA4282510 |
460 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA4282509 rs781887399 |
461 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1351727629 CA367991497 |
461 | P>S | No |
ClinGen TOPMed |
|
|
rs374287825 CA4282507 |
462 | V>I | No |
ClinGen ESP ExAC TOPMed |
|
|
CA367991477 rs1278505283 |
464 | Q>H | No |
ClinGen TOPMed |
|
|
rs761231834 CA4282505 |
466 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1554451142 CA367991463 |
467 | V>I | No |
ClinGen gnomAD |
|
|
CA4282504 rs782136742 |
468 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA367991440 rs1554451139 |
470 | D>G | No |
ClinGen gnomAD |
|
|
CA4282503 rs370356685 |
471 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1222610881 CA367991431 |
472 | S>G | No |
ClinGen TOPMed |
|
|
rs1281107025 CA367991428 |
472 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1554451129 CA367991418 |
473 | T>I | No |
ClinGen gnomAD |
|
|
CA367991400 rs1349089093 |
476 | S>G | No |
ClinGen TOPMed |
|
|
CA367991370 rs1255681717 |
480 | I>T | No |
ClinGen TOPMed |
|
|
rs782820408 CA4282502 |
480 | I>V | No |
ClinGen ExAC TOPMed |
|
|
CA160857215 rs782592841 |
481 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA4282499 rs781946026 |
481 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282497 rs782077327 |
482 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282496 rs781996061 |
482 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554451106 CA367991346 |
484 | L>R | No |
ClinGen gnomAD |
|
|
CA367991349 rs1554451109 |
484 | L>V | No |
ClinGen gnomAD |
|
|
CA367991336 rs1554451101 |
486 | K>Q | No |
ClinGen gnomAD |
|
|
CA367991332 rs1554451100 |
486 | K>R | No |
ClinGen gnomAD |
|
|
rs1554451095 CA367991307 |
489 | W>* | No |
ClinGen gnomAD |
|
|
CA4282492 rs782654345 |
489 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA367991301 rs1410250825 |
490 | Q>R | No |
ClinGen TOPMed |
|
|
rs1327575833 CA367991296 |
491 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
CA367991292 rs1333500049 |
491 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA4282489 rs782627197 |
494 | D>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA367991244 rs1440595322 |
498 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA367991243 rs1440595322 |
498 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA367991229 rs1306275500 |
500 | A>S | No |
ClinGen TOPMed |
|
|
CA4282487 rs782474383 |
500 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1554451079 CA367991226 |
501 | V>I | No |
ClinGen gnomAD |
|
|
rs563545212 CA4282485 |
502 | K>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 502 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1158788100 CA367991181 |
504 | Q>* | No |
ClinGen TOPMed |
|
|
CA160854128 rs766040186 |
505 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
CA4282467 rs528347907 |
505 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs879981057 CA367991168 |
506 | T>S | No |
ClinGen gnomAD |
|
|
rs1554439411 CA367991155 |
508 | Y>C | No |
ClinGen gnomAD |
|
|
rs1554439414 CA367991158 |
508 | Y>D | No |
ClinGen gnomAD |
|
|
rs1554439407 CA367991152 |
509 | R>G | No |
ClinGen gnomAD |
|
|
rs1281229403 CA367991135 |
511 | M>I | No |
ClinGen TOPMed |
|
|
rs28535321 CA367991137 |
511 | M>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282466 rs28535321 |
511 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs199818733 CA160854127 |
513 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282464 rs199818733 |
513 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 514 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367991102 rs1349751096 |
516 | W>* | No |
ClinGen TOPMed |
|
|
rs1279154771 CA367991091 |
518 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs782699835 CA367991078 |
519 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA4282458 rs782097585 |
520 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367991068 rs1183274336 |
521 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA4282457 rs781952818 |
521 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1563036907 CA367991063 |
522 | Q>* | No |
ClinGen Ensembl |
|
|
CA367991059 rs1470771218 |
522 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA367991044 rs372077121 |
524 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282454 rs193229651 |
525 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs368655650 CA4282453 |
525 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367991023 rs1441447026 |
528 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA367991025 rs1441447026 |
528 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA367991007 rs782620149 |
531 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA4282448 rs782620149 |
531 | G>W | No |
ClinGen ExAC gnomAD |
|
|
CA367990998 rs1554439342 |
532 | N>I | No |
ClinGen gnomAD |
|
|
CA4282446 rs782276717 |
533 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1302251611 CA367990980 |
535 | F>V | No |
ClinGen TOPMed |
|
|
rs1554439336 CA367990972 |
536 | I>F | No |
ClinGen gnomAD |
|
|
CA367990968 rs1342354253 |
536 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA367990965 rs1197060822 |
537 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA4282444 rs782435391 |
538 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782435391 CA4282443 |
538 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1436692434 CA367990950 |
539 | K>M | No |
ClinGen TOPMed |
|
|
rs782318142 CA4282429 |
540 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs782318142 CA4282430 |
540 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA4282426 rs782342055 |
541 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282427 rs782342055 |
541 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782264341 CA4282425 |
543 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs1554437012 CA367990914 |
544 | C>R | No |
ClinGen gnomAD |
|
|
rs201876441 CA4282424 |
545 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201876441 CA4282423 |
545 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1297151764 CA367990900 |
546 | E>* | No |
ClinGen TOPMed |
|
|
rs781889622 CA367990899 |
546 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781889622 CA4282422 |
546 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782445278 CA4282420 |
550 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367990867 rs1554437001 |
551 | S>G | No |
ClinGen gnomAD |
|
|
rs1313577110 CA367990858 |
552 | L>F | No |
ClinGen TOPMed |
|
|
rs1554436990 CA367990849 |
553 | T>S | No |
ClinGen gnomAD |
|
|
CA4282418 rs782736209 |
554 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs573176711 CA160853603 |
555 | A>P | No |
ClinGen Ensembl |
|
|
CA4282416 rs539703149 |
556 | H>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4282417 rs539703149 |
556 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782063418 CA4282414 |
557 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1554436978 CA367990822 |
558 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 559 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1554436975 CA367990808 |
560 | H>N | No |
ClinGen gnomAD |
|
|
CA4282413 rs112435417 |
560 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1554436973 CA367990801 |
561 | E>K | No |
ClinGen gnomAD |
|
|
rs1484006766 CA367990782 |
563 | V>A | No |
ClinGen TOPMed |
|
|
CA367990773 rs1554436971 |
565 | Q>K | No |
ClinGen gnomAD |
|
|
CA367990771 rs782083655 |
565 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782083655 CA4282411 |
565 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282410 rs782000871 |
566 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs782375997 CA4282409 |
566 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA4282407 rs367555373 |
568 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4282406 rs374889237 |
568 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs782616380 CA367990749 |
569 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA367990745 rs371157565 |
569 | E>D | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA367990751 rs782616380 |
569 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA4282404 rs782616380 |
569 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1554436954 CA367990738 |
571 | V>M | No |
ClinGen gnomAD |
|
|
rs531710796 CA4282402 |
572 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs531710796 CA4282403 |
572 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782532987 CA4282400 |
574 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782093082 CA4282397 |
575 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA367990704 rs1554436943 |
576 | E>D | No |
ClinGen gnomAD |
|
|
CA4282396 rs781821818 |
576 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 578 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1554436940 CA367990691 |
578 | E>G | No |
ClinGen gnomAD |
|
|
CA4282395 rs782780047 |
580 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA4282393 rs782038357 |
581 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782798588 CA4282392 |
581 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs782071422 CA4282391 |
582 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1554436929 CA367990658 |
583 | H>R | No |
ClinGen gnomAD |
|
|
CA4282389 rs782365190 |
584 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs782365190 CA367990654 |
584 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367990643 rs1554436923 |
585 | H>R | No |
ClinGen gnomAD |
|
|
CA4282388 rs782216181 |
586 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs782009016 CA4282387 |
587 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs782416097 CA4282386 |
588 | C>G | No |
ClinGen ExAC gnomAD |
|
|
rs1554436917 CA367990621 |
588 | C>W | No |
ClinGen gnomAD |
|
|
CA367990619 rs782275280 |
589 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782275280 CA4282385 |
589 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782581605 CA4282384 |
591 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs782591921 CA4282381 |
594 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA367990034 rs1201971575 |
598 | I>M | No |
ClinGen TOPMed |
|
|
rs782588999 CA4282356 |
598 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1554428339 CA367990032 |
599 | G>R | No |
ClinGen gnomAD |
|
|
rs1224479329 CA367990001 |
603 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
rs782505314 CA367989984 |
605 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782505314 CA4282352 |
605 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282353 rs782613762 |
605 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs200258949 CA367989975 |
607 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA160851924 rs200258949 |
607 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1426854771 CA367989971 |
607 | D>V | No |
ClinGen TOPMed |
|
|
CA367989974 rs200258949 |
607 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs781861322 CA4282351 |
608 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282349 rs541443405 |
610 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4282348 rs781814988 |
610 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282350 rs541443405 |
610 | R>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs782733840 CA4282347 |
611 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4282344 rs782385560 |
614 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs782385560 CA4282345 |
614 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA367989919 rs1585818524 |
615 | I>T | No |
ClinGen Ensembl |
|
|
rs1291190199 CA367989897 |
618 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs782030228 CA4282342 |
618 | Y>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782030228 CA367989899 |
618 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1291190199 CA367989896 |
618 | Y>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4282341 rs782305098 |
619 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1554428310 CA4282337 |
623 | G>A | No |
ClinGen Ensembl |
|
| TCGA novel | 623 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4282336 rs782355208 |
626 | T>K | No |
ClinGen ExAC gnomAD |
|
|
CA4282335 rs782355208 |
626 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA4282330 rs782552126 |
629 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA4282329 rs781795689 |
631 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1554428300 CA367989812 |
631 | D>N | No |
ClinGen gnomAD |
|
|
CA4282327 rs782485661 |
633 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782485661 CA4282328 |
633 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367989766 rs1216370291 |
637 | P>L | No |
ClinGen TOPMed |
|
|
rs1585818436 CA367989764 |
638 | H>N | No |
ClinGen Ensembl |
|
|
rs1243823516 CA367989750 |
639 | W>C | No |
ClinGen TOPMed |
|
|
rs1585818413 CA367989726 |
643 | G>R | No |
ClinGen Ensembl |
|
|
CA4282325 rs781843092 |
645 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1554428294 CA367989700 |
647 | R>G | No |
ClinGen gnomAD |
|
|
CA4282324 rs782764583 |
648 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367989666 rs1243915783 |
651 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs782134759 CA4282323 |
652 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA4282322 rs534463378 |
653 | D>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA367989645 rs1161977328 |
654 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1554428290 CA367989619 |
658 | R>K | No |
ClinGen gnomAD |
|
|
rs1554428289 CA367989615 |
658 | R>S | No |
ClinGen gnomAD |
|
|
CA367989604 rs1413488068 |
660 | N>Y | No |
ClinGen TOPMed |
|
|
rs1554428288 CA367989586 |
662 | S>* | No |
ClinGen Ensembl |
|
|
CA367989577 rs1554428287 |
663 | K>N | No |
ClinGen gnomAD |
|
|
CA4282320 rs782818822 |
665 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 666 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1401704328 CA367989555 |
667 | G>E | No |
ClinGen TOPMed |
|
|
CA367989541 rs1554428280 |
669 | C>S | No |
ClinGen gnomAD |
|
|
rs577012705 CA4282318 |
669 | C>W | No |
ClinGen 1000Genomes ExAC gnomAD |
No associated diseases with Q6NUM6
6 regional properties for Q6NUM6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Flavodoxin-like | 87 - 98 | IPR001094-1 |
| domain | Flavodoxin-like | 125 - 135 | IPR001094-2 |
| domain | Flavodoxin-like | 150 - 169 | IPR001094-3 |
| domain | Radical SAM | 336 - 580 | IPR007197 |
| domain | Flavodoxin/nitric oxide synthase | 37 - 191 | IPR008254 |
| domain | tRNA wybutosine-synthesis | 531 - 593 | IPR013917 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.3.44 | Oxo-acid-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| FMN binding | Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| metal ion binding | Binding to a metal ion. |
| tRNA-4-demethylwyosine synthase activity | Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| wybutosine biosynthetic process | The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NV66 | TYW1 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 | Homo sapiens (Human) | PR |
| Q8BJM7 | Tyw1 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 | Mus musculus (Mouse) | PR |
| Q08C92 | tyw1 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPSADTWDL | SSPLISLWIN | RFYIYLGFAV | SISLWICVQI | VIEMQGFATV | LAEAVTSLDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVAIINLKEY | DPDDHLIEEV | TSKNVCVFLV | ATYTDGLPTE | SAEWFCKWLE | EASIDFRFGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TYLKGMRDAV | FGLGNSAYAS | HFNKVGKNVD | KWLWMLGVHR | VMSRGEGDCD | VVKSKHGSIE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANFRAWKTKF | ISQLQALQKG | ERKKSCGGHC | KKGKCESHQH | GSEEREEGSQ | EQDELHHRDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEEEPFESSS | EEEFGGEDHQ | SLNSIVDVED | LGKIMDHVKK | EKREKEQQEE | KSGLFRNMGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEDGERRAMI | TPALREALTK | QVDAPRERSL | LQTHILWNES | HRCMETTPSL | ACANKCVFCW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WHHNNPVGTE | WLWKMDQPEM | ILKEAIENHQ | NMIKQFKGVP | GVKAERFEEG | MTVKHCALSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VGEPIMYPEI | NRFLKLLHQC | KISSFLVTNA | QFPAEIRNLE | PVTQLYVSVD | ASTKDSLKKI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DRPLFKDFWQ | QFLDSLKALA | VKQQRTVYRL | MLVKAWNVDE | LQAYAQLVSL | GNPDFIEVKG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VTYCRESSAS | SLTMAHVPWH | EEVVQFVREL | VDLIPEYEIA | CEHEHSNCLL | IAHRKFKIGG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EWWTWIDYNR | FQELIQEYED | SGGSKTFSAK | DYMARTPHWA | LFGANERSFD | PKDTRHQRKN |
| KSKAISGC |