Q6NUF4

PR
Gene name
tpx2-a
Protein name
Targeting protein for Xklp2-A
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398174
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-132 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q6NUF4

Entry ID Method Resolution Chain Position Source
3KND X-ray 215 A B 270-350 PDB
8CX6 NMR - A 477-716 PDB
AF-Q6NUF4-F1 Predicted AlphaFoldDB

No variants for Q6NUF4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NUF4

No associated diseases with Q6NUF4

5 regional properties for Q6NUF4

Type Name Position InterPro Accession
domain Aurora-A binding 1 - 55 IPR015128
domain TPX2, C-terminal 513 - 557 IPR027329-1
domain TPX2, C-terminal 629 - 703 IPR027329-2
domain TPX2 central domain 332 - 418 IPR027330-1
domain TPX2 central domain 415 - 458 IPR027330-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • Localizes during metaphase on spindle microtubules, with a strong enrichment at spindle poles
  • Localizes to the minus ends of spindle pole and aster microtubules in a dynein- and dynactin-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDTQDTYSY DAPSIFNFSS FHEDHNADSW FDQVTNAENI PPDQRRLSET SVNTEQNSKV
70 80 90 100 110 120
EPVQTTPSKD DVSNSATHVC DVKSQSKRSS RRMSKKHRQK LLVKMKDTHL EKETAPPEYP
130 140 150 160 170 180
PCKKLKGSSS KGRHAPVIKS QSTSSHHSMT SPKPKAQLTM PSTPTVLKRR NVLVKAKNSE
190 200 210 220 230 240
EQELEKMQEL QKEMLENLKK NEHSMKVAIT GAGQPVKTFI PVTKPVDFHF KTDDRLKRTA
250 260 270 280 290 300
NQPEGDGYKA VDFASELRKH PPSPVQVTKG GHTVPKPFNL SKGKRKHEEA SDYVSTAEQV
310 320 330 340 350 360
IAFYKRTPAR YHLRSRQREM EGPSPVKMIK TKLTNPKTPL LQTKGRHRPV TCKSAAELEA
370 380 390 400 410 420
EELEMINQYK FKAQELDTRI LEGGPVLLKK PLVKEPTKAI GFDLEIEKRI QQREKKEEIE
430 440 450 460 470 480
EETFTFHSRP CPSKMLTDVV GVPLKKLLPV TVPQSPAFAL KNRVRIPAQE EKQEEMVPVI
490 500 510 520 530 540
KATRMPHYGV PFKPKLVEQR QVDVCPFSFC DRDKERQLQK EKRLDELRKD EVPKFKAQPL
550 560 570 580 590 600
PQFDNIRLPE KKVKMPTQQE PFDLEIEKRG ASKLQRWQQQ IQEELKQQKE MVVFKARPNT
610 620 630 640 650 660
VVHQEPFVPK KENRSLTESL SGSIVQEGFE LATAKRAKER QEFDKCLAET EAQKSLLEEE
670 680 690 700 710
IRKRREEEEK EEISQLRQEL VHKAKPIRKY RAVEVKASDV PLTVPRSPNF SDRFKC