Q6NUC2

PR
Gene name
cops6 (csn6)
Protein name
COP9 signalosome complex subunit 6
Names
Signalosome subunit 6
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:414575
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NUC2

Entry ID Method Resolution Chain Position Source
AF-Q6NUC2-F1 Predicted AlphaFoldDB

No variants for Q6NUC2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NUC2

No associated diseases with Q6NUC2

3 regional properties for Q6NUC2

Type Name Position InterPro Accession
domain JAB1/MPN/MOV34 metalloenzyme domain 30 - 164 IPR000555
domain Rpn11/EIF3F, C-terminal 185 - 298 IPR024969
domain MPN domain 32 - 165 IPR037518

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAASNGNG MEVDVAALPS VMAQGVTGSV TVALHPLVIL NISDHWIRMR SQEGRPMQVI
70 80 90 100 110 120
GALIGKQEGR NIEVMNSFEL LSQINDEKIT INKEYYYTKE EQFKQVFKDM EFLGWYTTGG
130 140 150 160 170 180
TPDPSDIHVH KQVCEIIESP LFLKLNPMTK HTDLPVSVYE SVIDIVNGEA TMLLAELSYT
190 200 210 220 230 240
LATEEAERIG VDHVARMTAT GSGENSTVAE HLIAQHSAIK MLHSRVRLIL EYVRAAEGGE
250 260 270 280 290 300
VPFNHEILRE ASALCHCLPV LSTDKFKTDF YDQCNDVGLM SYLGTITKTC NTMNQFVNKF
310
NILYDRQGIG RRMRGLFF