Q6NTY6

PR
Gene name
egr1-b
Protein name
Early growth response protein 1-B
Names
EGR-1-B
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:414518
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NTY6

Entry ID Method Resolution Chain Position Source
AF-Q6NTY6-F1 Predicted AlphaFoldDB

No variants for Q6NTY6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NTY6

No associated diseases with Q6NTY6

5 regional properties for Q6NTY6

Type Name Position InterPro Accession
domain Zinc finger C2H2-type 284 - 313 IPR013087-1
domain Zinc finger C2H2-type 314 - 341 IPR013087-2
domain Zinc finger C2H2-type 342 - 369 IPR013087-3
repeat Early growth response protein 1, C-terminal 376 - 462 IPR021839
domain Early growth response, N-terminal 78 - 184 IPR021849

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
double-stranded methylated DNA binding Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
hemi-methylated DNA-binding Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
promoter-specific chromatin binding Binding to a section of chromatin that is associated with gene promoter sequences of DNA.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALAKTDMLV SPLQISDPFS SFPHSPTMDN YPKLDGAEQF DHHAADAFSE MSLSNEKAVL
70 80 90 100 110 120
ESSYANHTTR LPSLTYTGRF SLEPAPNSSN TLWPEPLFSL VSGLVGMANV SSSSAPSSSP
130 140 150 160 170 180
SSSSSSSSSS SSQSPPLSCS VQSNESSPIY SAAPTFPNSS PEMFPDHSPQ PFQNASTASI
190 200 210 220 230 240
PYPPPAYPVS KTTFQVPMIP DYLFPQQQGD VSLVSADQKP FQAMENRTQQ PSLTPLSTIK
250 260 270 280 290 300
AFATQTSQDL KTINSTYQSQ IIKPSRMRKY PNRPSKTPPH ERPYACPVES CDRRFSRSDE
310 320 330 340 350 360
LTRHIRIHTG QKPFQCRICM RNFSRSDHLT THIRTHTGEK PFACDICGRK FARSDERKRH
370 380 390 400 410 420
TKIHLRQKDK KADKATPVSI ASPVSAYSPS ASTSYPSPVP TSYSSPVSSC YPSPVHSSFP
430 440 450 460 470
SPTTAVTYPS VTSTFQTQCI TSFPSSIVTN SYSSPVSSAL SDMSVTYSPR TIEIC