Q6NS46
PR
Gene name |
Pdcd11 (Alg4, Kiaa0185) |
Protein name |
Protein RRP5 homolog |
Names |
Apoptosis-linked gene 4 protein, Programmed cell death protein 11 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18572 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NS46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NS46-F1 | Predicted | AlphaFoldDB |
90 variants for Q6NS46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs39317316 | 24 | Q>R | No | EVA | |
| rs3389554666 | 46 | K>R | No | EVA | |
| rs262005436 | 47 | S>G | No | EVA | |
| rs3389537873 | 61 | K>E | No | EVA | |
| rs3389548839 | 62 | R>S | No | EVA | |
| rs36683899 | 92 | E>D | No | EVA | |
| rs263539243 | 182 | D>E | No | EVA | |
| rs37055989 | 208 | V>I | No | EVA | |
| rs3389544852 | 231 | A>D | No | EVA | |
| rs3389545440 | 232 | K>N | No | EVA | |
| rs3389538391 | 270 | E>K | No | EVA | |
| rs36692969 | 274 | N>S | No | EVA | |
| rs3389554640 | 297 | Q>H | No | EVA | |
| rs3409516172 | 300 | F>C | No | EVA | |
| rs3408180701 | 301 | L>I | No | EVA | |
| rs3389501384 | 356 | L>F | No | EVA | |
| rs3389452719 | 400 | S>T | No | EVA | |
| rs3389555841 | 415 | S>I | No | EVA | |
| rs3389546275 | 452 | I>L | No | EVA | |
| rs3389537832 | 474 | E>D | No | EVA | |
| rs218859565 | 486 | A>T | No | EVA | |
| rs3389540943 | 520 | T>I | No | EVA | |
| rs31239647 | 531 | S>P | No | EVA | |
| rs3389538344 | 538 | G>D | No | EVA | |
| rs3389545401 | 543 | L>P | No | EVA | |
| rs3389560477 | 549 | I>M | No | EVA | |
| rs3389537818 | 551 | R>W | No | EVA | |
| rs262511045 | 558 | I>V | No | EVA | |
| rs229983050 | 564 | D>H | No | EVA | |
| rs3389545414 | 567 | G>W | No | EVA | |
| rs3409133590 | 580 | P>S | No | EVA | |
| rs256890636 | 584 | T>A | No | EVA | |
| rs37785984 | 617 | R>G | No | EVA | |
| rs37183561 | 622 | G>S | No | EVA | |
| rs239817623 | 625 | S>N | No | EVA | |
| rs228946098 | 634 | R>H | No | EVA | |
| rs37779196 | 634 | R>S | No | EVA | |
| rs3389453492 | 648 | K>R | No | EVA | |
| rs3389537848 | 670 | S>T | No | EVA | |
| rs3389554723 | 690 | H>Q | No | EVA | |
| rs227250370 | 697 | Q>K | No | EVA | |
| rs3408928080 | 741 | E>D | No | EVA | |
| rs3389537815 | 752 | L>P | No | EVA | |
| rs3389548841 | 767 | T>I | No | EVA | |
| rs3389554648 | 781 | A>D | No | EVA | |
| rs3389537835 | 839 | T>R | No | EVA | |
| rs227161191 | 878 | R>K | No | EVA | |
| rs246122446 | 919 | T>P | No | EVA | |
| rs259159156 | 971 | R>H | No | EVA | |
| rs3389560536 | 989 | G>A | No | EVA | |
| rs3409516210 | 1044 | L>Q | No | EVA | |
| rs3408606442 | 1047 | G>R | No | EVA | |
| rs3389560528 | 1139 | S>R | No | EVA | |
| rs3389511434 | 1169 | K>N | No | EVA | |
| rs3389555916 | 1172 | V>L | No | EVA | |
| rs3389511467 | 1194 | T>I | No | EVA | |
| rs3389501473 | 1216 | A>V | No | EVA | |
| rs3389501390 | 1253 | P>S | No | EVA | |
| rs3389525207 | 1268 | K>T | No | EVA | |
| rs3389537844 | 1271 | M>R | No | EVA | |
| rs3389544842 | 1285 | D>N | No | EVA | |
| rs3389525270 | 1357 | S>L | No | EVA | |
| rs243995460 | 1380 | G>R | No | EVA | |
| rs3389453490 | 1383 | P>H | No | EVA | |
| rs3389545413 | 1384 | E>V | No | EVA | |
| rs232831274 | 1394 | R>C | No | EVA | |
| rs3389453502 | 1398 | M>I | No | EVA | |
| rs3389501417 | 1412 | G>R | No | EVA | |
| rs243610871 | 1429 | S>R | No | EVA | |
| rs225202418 | 1442 | N>K | No | EVA | |
| rs263221067 | 1442 | N>S | No | EVA | |
| rs3389555899 | 1505 | E>D | No | EVA | |
| rs38603612 | 1517 | S>P | No | EVA | |
| rs3389525190 | 1537 | S>P | No | EVA | |
| rs3389493199 | 1555 | Q>L | No | EVA | |
| rs222867689 | 1556 | P>L | No | EVA | |
| rs3389453579 | 1556 | P>S | No | EVA | |
| rs3389560496 | 1557 | H>Y | No | EVA | |
| rs3389493160 | 1585 | A>T | No | EVA | |
| rs3389546258 | 1593 | P>S | No | EVA | |
| rs3389544856 | 1594 | E>D | No | EVA | |
| rs3389555919 | 1659 | E>* | No | EVA | |
| rs3389537833 | 1680 | E>D | No | EVA | |
| rs36767854 | 1698 | Y>F | No | EVA | |
| rs3409306874 | 1699 | K>Q | No | EVA | |
| rs3389544834 | 1728 | G>E | No | EVA | |
| rs3389555914 | 1731 | Q>H | No | EVA | |
| rs3389453533 | 1745 | C>Y | No | EVA | |
| rs3389548791 | 1749 | K>N | No | EVA | |
| rs3389548773 | 1825 | F>L | No | EVA |
No associated diseases with Q6NS46
1 regional properties for Q6NS46
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytochrome b5-like heme/steroid binding domain | 97 - 195 | IPR001199 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| NF-kappaB binding | Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANLEESFPR | GGTRKLHKSE | KSSQQVVEQD | NLFDVSTEEG | PIKRKKSQKG | PAKTKKLKIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRKSIKSIKE | KFEILSLESL | CEGMRILGCV | KEVSELELVV | SLPNGLQGFV | QVTEVCDAYT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QKLNEQVAQE | EPLEDLLRLP | ELFSPGMLVR | CVVSSLDVTE | SGKKSVKLSV | NPKRVNKVLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADALRPGMLL | TGTVSSLEDH | GYLVDIGVGG | TRAFLSLKKA | QEYIRQKNKG | AKFKVGQYLT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CVVEEVKSNG | GVVSLSVEHS | EVSSAFATEE | QSWNLNNLLP | GLLVKAQVQK | VTQFGLQLNF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTFFKGLVDF | MHLEPKKMGS | YSSNQTVKAC | ILCVHPRTRV | VRLSLRPIFL | HPGRPLTRIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQQLGAVLDD | VPVQGFFKNA | GAIFRLKDGV | LAYARVSHLS | DSKKAFNAEA | FKPGSTHKCR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IIDYSQMDEL | ALLSLRKSII | AAPFLRYHDI | KIGTVVKGTV | LAIKPFGILV | KVGEQIKGLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSMHLADIMM | KNPEKKYSPG | DEVKCRVLLC | DPEAKKLIMT | LKKTLVTSKL | SLITCYEGAK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PGLQTHGVII | RVKDYGCIVK | FYNDVQGLVP | KHELSTQHIP | DPETVFYTGQ | VVKVAVLSCE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PSKERMLLSF | RLLSDSRPKD | PGVESSQKKT | GAVRIGQLVD | VKVLEKTKTG | LEVAILPHNT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PAFLPTPHLS | DHAANGPLLH | HWLQTGDTLH | RVLCLSQSER | HILLCRKPAL | VSTVEGGQDP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KSLSEIQPGM | LLIGFVKCIK | EYGVFVQFPS | GLSGLSPKTI | MSDKFVTTPS | EHFVEGQTVV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AKVTNVDESK | QRMLLSLRLS | DCSLGDSAST | SFLLLCQCLE | ELQGIRSLMS | NQDSVLIQTL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ADMTPGMVLD | AVVHEVLEDG | SVVFSSDPVP | DLVLRASRYH | RAGQEVEPGQ | KKKVVVLHVD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MLKLEVHVSL | HQDLVNRKTR | KLRKSSRHQG | IVQHLEESFA | VASLVETGHL | VAFSLISHLN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DTFHFDSEKL | RVGQGVCLTL | KTTEPGVTGL | ILAVEGPASK | RTRMPVQRDS | ETVDDKGEEK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EEEEEEEEKE | EENLTVKSKK | RHSLAIGDKV | TGTIKAVKAT | HVVVTLADGF | VGCIHASRIL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DDVPVGTSPT | TTLKAGKKVT | ARVIGGRDVK | TSKFLPISHP | RFVLTILELS | VRPSELKGSY |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SALNTHSESP | VEKIRQYQAG | QTVTCFFKKY | NVMKKWLEVD | IGPDIRGRIP | LLLTSLSFKV |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LKHPDKKFQV | GQAIEATVVD | PDVPRAFLCL | SLIGPYRLEE | GEVAMGRVMK | VVPNRGLTVS |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| FPFGKIGKVS | MFHLSDSYSE | APLEDFCPQK | IVRCYILSTA | HRVLALSLRS | SRTNRETKNR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| IEDPEINSIE | DVKEGQLLRG | YVKCVLPSSV | IIGLGPSVLG | LAKYSHVSEC | VPPEKELYNG |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| CLPEGKLVTA | KVLRVNPMKN | LIELSLLPSD | TGRPDVFSPA | PEPKQEERSG | GAEEGQKRKE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KNQKRREEKE | EPQKSQRGGR | GKRERQESES | EQELVNKRPK | KSGAAEEDDS | GVEVYYREGE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| DEVGEPKLPP | RGKQTKSTEV | PRLHLSSGFL | WDVGLDSLTP | ALPLREESSD | SEDEQPHQAK |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| KKKGKKEREL | EKQKAEKELS | RIEEALMDPG | RQPESADDFD | RLVLSSPNSS | ILWLQYMAFH |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LQATEIEKAR | AVAERALKTI | SFREEQEKLN | VWVALLNLEN | MYGSQESLTK | VFERAVQYNE |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| PLKVFLHLAD | IYTKSEKYKE | AGELYNRMLK | RFRQEKAVWI | KYGAFVLGRS | QAGASHRVLQ |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| RALECLPAKE | HVDVIVKFAQ | LEFQLGDVER | AKAIFENTLS | TYPKRTDVWS | VYIDMTIKHG |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| SQTAVRDIFE | RVIHLSLAPK | RMKFFFKRYL | DYEKQHGTEK | DVQAVKAKAL | EYVEAKSSAL |
| ED |