Q6NRV4

PR
Gene name
rdh10-b
Protein name
Retinol dehydrogenase 10-B
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:431995
EC number
1.1.1.300: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

293-341 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NRV4

Entry ID Method Resolution Chain Position Source
AF-Q6NRV4-F1 Predicted AlphaFoldDB

No variants for Q6NRV4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NRV4

No associated diseases with Q6NRV4

1 regional properties for Q6NRV4

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 197 - 225 IPR020904

Functions

Description
EC Number 1.1.1.300 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Microsome membrane ; Single-pass membrane protein
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.

1 GO annotations of biological process

Name Definition
retinoic acid biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHIVLEFFLV TFRVLWAFVL AAAKWFVRPK DKNVAGQVCL ITGAGSGLGR LFALEFARRR
70 80 90 100 110 120
AQLVLWDINP QSNEETADMV RDIYRQLQAE DSARRANSSA DEEVLPCCNL QVYTYTCDVG
130 140 150 160 170 180
KRESVYSTAE RVRREVGDVY LLLNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF
190 200 210 220 230 240
LPKMMEMNHG HIVSVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA ADKDGIKTTL
250 260 270 280 290 300
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMRAI LTDQPMICTP RLMYIVLCMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNETKNG I