Q6NRT3

PR
Gene name
smu1
Protein name
WD40 repeat-containing protein SMU1
Names
Smu-1 suppressor of mec-8 and unc-52 protein homolog
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:431914
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-183 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NRT3

Entry ID Method Resolution Chain Position Source
AF-Q6NRT3-F1 Predicted AlphaFoldDB

No variants for Q6NRT3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NRT3

No associated diseases with Q6NRT3

6 regional properties for Q6NRT3

Type Name Position InterPro Accession
repeat WD40 repeat 478 - 561 IPR001680-1
repeat WD40 repeat 700 - 745 IPR001680-2
repeat WD40 repeat 749 - 788 IPR001680-3
repeat WD40 repeat 800 - 843 IPR001680-4
domain BOP1, N-terminal domain 218 - 478 IPR012953
conserved_site WD40 repeat, conserved site 504 - 518 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Nucleus speckle
  • Colocalizes with srsf1 in nuclear speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSIEIESSDV IRLIMQYLKE NSLHRTLATL QEETTVSLNT VDSIESFVAD INSGHWDTVL
70 80 90 100 110 120
QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQNQ SERYIHLENL
130 140 150 160 170 180
LARSYFDPRE AYPDGSSKEK RRTAIAQALA GEVSVVPPSR LMALLGQALK WQQHQGLLPP
190 200 210 220 230 240
GMTIDLFRGK AAVKDVEEEK FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV
250 260 270 280 290 300
WNFTTGKIRK DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
310 320 330 340 350 360
RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS FVNEATFTQD
370 380 390 400 410 420
GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV NSVILLPKNP EHFVVCNRSN
430 440 450 460 470 480
TVVIMNMQGQ IVRSFSSGKR EGGDFVCCTL SPRGEWIYCV GEDFVLYCFS TVTGKLERTL
490 500 510
TVHEKDVIGI AHHPHQNLIG TYSEDGLLKL WKP