Q6NRL2

PR
Gene name
snx33 (sh3px3)
Protein name
Sorting nexin-33
Names
SH3 and PX domain-containing protein 3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:431808
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-247 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NRL2

Entry ID Method Resolution Chain Position Source
AF-Q6NRL2-F1 Predicted AlphaFoldDB

No variants for Q6NRL2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NRL2

No associated diseases with Q6NRL2

4 regional properties for Q6NRL2

Type Name Position InterPro Accession
domain SH3 domain 1 - 61 IPR001452
domain Phox homology 203 - 316 IPR001683
domain Sorting nexin protein, WASP-binding domain 313 - 548 IPR019497
domain Sorting nexin-33, BAR domain 341 - 547 IPR037427

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Primarily detected in the cytosol
  • A minor proportion is membrane-bound (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

8 GO annotations of biological process

Name Definition
cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
macropinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALKARALYS FQGENKEEIN LMENEELQLL SDVSLDGWLQ GTNSRGQTGL FPASYVEIQS
70 80 90 100 110 120
SRSGSVQVDY SGNAREYTDP PHQGSYDDDD EEDDDDWDDW DDGQTVVDEP SGSNGVSRSE
130 140 150 160 170 180
LQHHHHYSRP EYSHRPRPAL ERQDSIASGK RGSVVGRNLN RFSSFVRSGV EAFVLGDVPQ
190 200 210 220 230 240
FGGVAESHAI EMAPKGPQWK ANPRPFNCSV EEPTKQTKFK GIKSYISYRL TPDHSNSPVY
250 260 270 280 290 300
RRYKHFDWLY NRLLHKFTVI SLPHLPEKQA TGRFEEDFIQ KRKRRLVLWM DHMTSHPVLS
310 320 330 340 350 360
QYDGFQHFLG CQDEKQWKAG KRRAERDELV GASFLLTLQL PTEHQDLQDV EERVDVFKAF
370 380 390 400 410 420
SKKMDESVLQ LSSVVSELAR KHLGGFRKEF QKLGAAFQGL SHSFQLDPPY SSEPLVGAIS
430 440 450 460 470 480
HTGRTYEAVG EMFAEQPKND QFRFLDTLSL YQGLLSNFPD IIHLQKGAFA KVKDSQRMSD
490 500 510 520 530 540
EGRMEQDEAD GVRKRCRVVG FALQAEINHF HQRRLLDFKQ AIQHYLKEQI IFYRRVSQEL
EKTLHLYDEL