Q6NIA5

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP0872
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

548-610 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NIA5

Entry ID Method Resolution Chain Position Source
AF-Q6NIA5-F1 Predicted AlphaFoldDB

No variants for Q6NIA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NIA5

No associated diseases with Q6NIA5

9 regional properties for Q6NIA5

Type Name Position InterPro Accession
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 432 - 527 IPR013155
domain Methionyl/Leucyl tRNA synthetase 5 - 411 IPR015413
domain Methioninyl-tRNA synthetase core domain 7 - 20 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 40 - 54 IPR033911-2
domain Methioninyl-tRNA synthetase core domain 88 - 99 IPR033911-3
domain Methioninyl-tRNA synthetase core domain 253 - 264 IPR033911-4
domain Methioninyl-tRNA synthetase core domain 293 - 308 IPR033911-5
domain Methioninyl-tRNA synthetase core domain 399 - 410 IPR033911-6
domain Methionyl-tRNA synthetase, anticodon-binding domain 396 - 524 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNRVLVSVA WPYANGPRHI GHVAGFGVPS DVFARYQRMS GAEVLMVSGT DEHGTPLLVQ
70 80 90 100 110 120
ADKEGVSVKE LADRYNRQIV EDLAGLGLSY DLFTRTTTRN HYAVVQDLFK GLYENGYMIK
130 140 150 160 170 180
ETTMGAVSPS TGRTLPDRYI EGTCPICGAS GARGDQCDNC GNQLDPADLI NPVSKINGET
190 200 210 220 230 240
PKFIETEHFL LDLPALADAL AAWLKDRKDW RPNVLKFSLN LLEDLRPRAM SRDIDWGIPI
250 260 270 280 290 300
PVEGWQDNGA KKLYVWFDAV VGYLSASIEW AYRTGDPEAW KKWWNDPESS GYYFMGKDNI
310 320 330 340 350 360
TFHSQIWPAE LLGYQGKGAK AGSVHSLGEL NLPTEVVSSE FLTMSGSKFS SSKGIVIYVK
370 380 390 400 410 420
DFLKEFGADP LRYFIAVAGP ENNDTDFTWD EFVRRVNNEL ANGWGNLVNR TVSMAYKNFG
430 440 450 460 470 480
EVPTPGELTE SDKKILAQAE EAFGVVGEAL AHSRFKQGIT HAMHIVGEAN AYIAEQEPWK
490 500 510 520 530 540
LAKDESQRER LATVLWTALQ VVSDCNVLLT PYLPHIAQQV HETLGRDGVW AAKPQIVEVT
550 560 570 580 590 600
DDMPVEPIGV GIPEAGQTYP VIMGDYAAQQ ARWARIDVQP GTALSKPKPL IAKLDPELGE
TGPEWAPVNP