Q6NHU3

PR
Gene name
thrB
Protein name
Homoserine kinase
Names
HK, HSK
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP1037
EC number
2.7.1.39: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NHU3

Entry ID Method Resolution Chain Position Source
AF-Q6NHU3-F1 Predicted AlphaFoldDB

No variants for Q6NHU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NHU3

No associated diseases with Q6NHU3

2 regional properties for Q6NHU3

Type Name Position InterPro Accession
conserved_site GHMP kinase, ATP-binding, conserved site 94 - 105 IPR006203
domain GHMP kinase N-terminal domain 87 - 148 IPR006204

Functions

Description
EC Number 2.7.1.39 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
homoserine kinase activity Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIELPVGKK VTVTVPASSA NLGPGFDTLG LALSLYDTVE VEVTDHGLEV EVFGEGQGEL
70 80 90 100 110 120
PLDGSHLVVK AIRAGLKAAD VQVPGLRVVC HNNIPQSRGL GSSAAAAVAG VAAANGLAGF
130 140 150 160 170 180
PLDDARVVQL SSAFEGHPDN AAASVLGNAV VSWTEIPVDG RTEPQFKAVT INVDSRIKAT
190 200 210 220 230 240
ALVPDFHAST EAVRRVLPSD VTHLDARFNV SRCAVMTVAL QHHPELLWEG TRDRLHQPYR
250 260 270 280 290 300
ADVLPVTAEW VNRLRNRGYA AYLSGAGPTI MVLHTEPVDE AVLNDAREAG LRVLSLDVAD
AVSVKVDA