Q6NHG4

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP1174
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NHG4

Entry ID Method Resolution Chain Position Source
AF-Q6NHG4-F1 Predicted AlphaFoldDB

No variants for Q6NHG4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NHG4

No associated diseases with Q6NHG4

3 regional properties for Q6NHG4

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 284 - 293 IPR020557
domain Fumarate lyase, N-terminal 14 - 309 IPR022761
domain Argininosuccinate lyase, C-terminal 372 - 440 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKHGTNEGA LWGGRFSGGP SEAMFALSVS THFDWVLAPY DVLASKAHAR VLNKAKLLSD
70 80 90 100 110 120
SDLETMLGGL DKLGKAVASG EFKPLPTDED VHGAMERGLI DIVGPEVGGR LRAGRSRNDQ
130 140 150 160 170 180
VATLFRMWVR DAVRSVALQV TELVDALAYQ ATQHPRAIMP GKTHSQAAQP VLLAHQLLAH
190 200 210 220 230 240
AQPLLRDIDR IRDLDKRLAI SPYGSGALAG SSLHLDPEAI AQELGFDSAC DNSIDGTSSR
250 260 270 280 290 300
DFAAETAYVL AQIAIDMSRL AEEIIYWCTP EYGYVTLSDA WSTGSSIMPQ KKNPDVAELT
310 320 330 340 350 360
RGKTGRLIGN LSGLLATLKA QPLAYNRDLQ EDKEPIVDSF AQLNLLLPAM TGLVSTLTFH
370 380 390 400 410 420
EDRLLSLAPA GFTLATDLAE WMVRQGVPFR EAHEASGACV RIAESRGVGL DELTDDELAS
430 440 450 460 470
VDVRLTPEVR TVLTVEGAVA SRATRGGTAG VRVEEQRSRV ESTSQSFKEW ALTPVRK