Q6NGD8

PR
Gene name
dinB
Protein name
DNA polymerase IV
Names
Pol IV
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP1588
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

328-421 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NGD8

Entry ID Method Resolution Chain Position Source
AF-Q6NGD8-F1 Predicted AlphaFoldDB

No variants for Q6NGD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NGD8

No associated diseases with Q6NGD8

3 regional properties for Q6NGD8

Type Name Position InterPro Accession
domain UmuC domain 5 - 187 IPR001126
domain DNA polymerase, Y-family, little finger domain 244 - 348 IPR017961
conserved_site DNA polymerase type-Y, HhH motif 170 - 199 IPR024728

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
magnesium ion binding Binding to a magnesium (Mg) ion.

3 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRWVIHVDM DAFFASCEQL TRPTLRGRPV LVGGASGRGV VAGASYEART FGARSAMPMY
70 80 90 100 110 120
QAKALIGMRG VVVSPRFAVY RAASQRVFSI LERMGGTVEK ISIDEGFVEP PELYGASASE
130 140 150 160 170 180
VDTWAQRLRA VIRDETGLPA SVGGGAGKQV AKICSDLAKP DGIYLCAASE HEEKMYPLPV
190 200 210 220 230 240
GRLWGVGPVT RTKLQQLGVE TIGDLARMSE REIDISLGTT VGRSLWRLAQ GHDDREVAPR
250 260 270 280 290 300
AIAKQISVEH TYPKDLVTSR AVDTAIIRAS RESHRRLLDD GRGARTVSVK LRMADFRIES
310 320 330 340 350 360
RSATLPYATD NLDTVTATAL KLARYPDEVG PIRLVGVGLS GLEDARQDIL FPELDRVVPV
370 380 390 400 410 420
KDTDFEVGVS DPHDSDLEIS TTDESPTAIG WRATQDIWHP DYGHGWVQGL GHGKITVRFE
430 440 450
TRTTGPGKVR TFDTNDALLS SADPINSLDW S