Q6NF05

PR
Gene name
clpB (DIP2104)
Protein name
Chaperone protein ClpB
Names
Species
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
KEGG Pathway
cdi:DIP2104
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NF05

Entry ID Method Resolution Chain Position Source
AF-Q6NF05-F1 Predicted AlphaFoldDB

No variants for Q6NF05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NF05

No associated diseases with Q6NF05

9 regional properties for Q6NF05

Type Name Position InterPro Accession
domain AAA+ ATPase domain 199 - 345 IPR003593-1
domain AAA+ ATPase domain 598 - 756 IPR003593-2
domain ATPase, AAA-type, core 204 - 318 IPR003959-1
domain ATPase, AAA-type, core 597 - 748 IPR003959-2
domain Clp, repeat (R) domain 1 - 147 IPR004176
conserved_site ClpA/B, conserved site 1 296 - 308 IPR018368
domain Clp ATPase, C-terminal 755 - 846 IPR019489
conserved_site ClpA/B, conserved site 2 632 - 650 IPR028299
domain ClpA/ClpB, AAA lid domain 344 - 444 IPR041546

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

2 GO annotations of biological process

Name Definition
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGFNPTTKT QEALQEALQK ASAAGNPDIR PEHLLAAILG QEDGIAIPVL RATGVDPDVV
70 80 90 100 110 120
RREAEALVAK LPKAEGANLA NPNFNRDALS VLNNAQELAG ELGDEYVSTE VLLAAVARGT
130 140 150 160 170 180
NDAAELLTKR GATYDVIKGV FPSVRGNKKV TTESPEDQFQ ALEKYSTDLT ARAREGKIDP
190 200 210 220 230 240
VIGRDQEIRR VVQVLSRRTK NNPVLIGEPG VGKTAIVEGL ARRIVAGDVP ESLKGKTLIS
250 260 270 280 290 300
LDLGSMVAGA KYRGEFEERL KAVLDEIKSA EGEIITFIDE LHTIVGAGAT GDSAMDAGNM
310 320 330 340 350 360
IKPLLARGEL RLVGATTLDE YRKYIEKDAA LERRFQQVFV GEPSVEDAVG ILRGLKERYE
370 380 390 400 410 420
VHHGVRIQDS ALVAAATLSD RYITSRFLPD KAIDLVDEAA SRLRMEIDSS PQEIDELERI
430 440 450 460 470 480
VRRLEIEEVA LSKETDAASK DRLIKLRQEL ADEREKLGEL VARWNNEKGA INKVREAKEE
490 500 510 520 530 540
LERLRSESEI AERDGDYGKV AELRYGRIPE LEKQVAEAEE HTVETTMLSE EVTPDTIAEV
550 560 570 580 590 600
VSAWTGIPAG KMLQGETEKL LNMEAELGKR VVGQSEAVVA VSDAVRRARA GVADPNRPTG
610 620 630 640 650 660
SFLFLGPTGV GKTELAKALA EFMFDDDRAM VRIDMSEYGE KHAVARLVGA PPGYVGYDQG
670 680 690 700 710 720
GQLTEAVRRR PYTVVLFDEV EKAHPDVFDI LLQVLDEGRL TDGQGRTVDF RNTVLILTSN
730 740 750 760 770 780
LGAGGTKDEM MDAVKRAFKP EFVNRLDDVV IFDPLSQEQL THIVEIQIAQ LAQRLAARRL
790 800 810 820 830 840
TLAVSDSAKL WLAERGYEPA YGARPLRRLI QQAIGDQLAK KLLSGEVRDG SEVHVDADLD
NDGLVISAS