Q6N1M8

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
KEGG Pathway
rpa:RPA4377
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6N1M8

Entry ID Method Resolution Chain Position Source
AF-Q6N1M8-F1 Predicted AlphaFoldDB

No variants for Q6N1M8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6N1M8

No associated diseases with Q6N1M8

4 regional properties for Q6N1M8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 70 - 81 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 40 - 708 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 753 - 881 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 708 - 885 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDKPKTDAA QSGNDYSKTL FLPQTEFPMR AGLPQREPEL LKRWEEMDLY GKLRESARGR
70 80 90 100 110 120
AKFVLHDGPP YANGNIHIGH ALNKILKDVV TKSQQMLGFD SNYVPGWDCH GLPIEWKIEE
130 140 150 160 170 180
ENYRSKGKPK PNFKDSAAII AFRKECRAYA DKWLNVQREE FKRLGVIGDW DHPYATMNYA
190 200 210 220 230 240
AEAQIARELM KFAANGTLYR GSKPVMWSVV EKTALAEAEV EYEDYTSDTV WVKFPVKTGD
250 260 270 280 290 300
ASTKDASVVI WTTTPWTLPG NRAISFSSKI AYGLYKVTDA PADNWAKTGD LLILADGLAE
310 320 330 340 350 360
SVFKQARVVA YEKVSDVGAD VLKASECAHP LQGLAGGYEF TVPLLDGDHV TDDTGTGFVH
370 380 390 400 410 420
TAPGHGREDF DIWMHNARAL EARGISSVIP YTVDENGALT EQAPGFTGKR VINDKGEKGD
430 440 450 460 470 480
ANEAVIQALI ARGALLARGK LKHQYPHSWR SKKPVIFRNT PQWFIAMDKD IVDDGVAKPG
490 500 510 520 530 540
DTLRARALQA ISVTQWVPPA GQNRINGMIS GRPDWVISRQ RAWGVPIAVF IKDKGDGSVE
550 560 570 580 590 600
ILQDEIVNQR IAEAFMQEGA DAWYAEGAAE RFLGDRAAEG WRKVDDILDV WFDSGSTHAF
610 620 630 640 650 660
VLEDAQNFPG LAGIRRKVDG GADTVMYLEG SDQHRGWFHS SLLESCGTRG RAPYDVVLTH
670 680 690 700 710 720
GFTLDEQGRK MSKSLGNTTD PAKVIASSGA DILRLWVCAT DYADDQRIGP EILKNVVETY
730 740 750 760 770 780
RKLRNSIRWM LGTLHHYHRD EAVAFADMPE LERLMLHQLA EQSATVRAAY AEFDYKTVVA
790 800 810 820 830 840
SLAAFMNTEL SAFYFDIRKD TLYCDPPSSL ARKAALTTID IICDAILKWL APVLSFTADE
850 860 870 880 890 900
AWSMYRPDAE PSVHLTLFPL DLGEYRDDAL AKKWTLIRAV RRVVTGALEV ERAAKRIGSS
910 920 930 940 950 960
LEASPMIYLP EAFMGDIFDV DWAEICITSN AMVEILRGND TPPADAFRLP ELADVAVVVE
970 980 990 1000
RAQGTKCARS WKILSSVGSD AEYPDVSPRD AQALREWKAL GGAAA