Q6MR11

PR
Gene name
ctaB
Protein name
Protoheme IX farnesyltransferase
Names
Heme B farnesyltransferase, Heme O synthase
Species
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)
KEGG Pathway
bba:Bd0290
EC number
2.5.1.141: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6MR11

Entry ID Method Resolution Chain Position Source
AF-Q6MR11-F1 Predicted AlphaFoldDB

No variants for Q6MR11

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6MR11

No associated diseases with Q6MR11

5 regional properties for Q6MR11

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 148 - 156 IPR000629
domain Helicase, C-terminal 214 - 375 IPR001650
domain DEAD/DEAH box helicase domain 26 - 191 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 21 - 218 IPR014001
domain RNA helicase, DEAD-box type, Q motif 2 - 30 IPR014014

Functions

Description
EC Number 2.5.1.141 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
protoheme IX farnesyltransferase activity Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.

1 GO annotations of biological process

Name Definition
heme O biosynthetic process The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRIYADLTK FGIVVFSVLA GLAGYATGFQ IENPFDWKIF LETLLGIYFL SSGSLALNQV
70 80 90 100 110 120
QDWKIDQKMP RTAKRPIPSG KIKPAAAGIL SVGLLLVGMN MLFKLEPVAG WVGLFCVFLY
130 140 150 160 170 180
NGPYTLWWKR RWVFAAVPGA IPGALPVTIG YAVANPDIFN SESLYLFLIM FLWQMPHFWV
190 200 210 220 230 240
LAIRYKDDYA AGGIPTLPVA LGMEKTMFQV GLYTLVYVGV ALAAPMFVHA SWMFVLLTFP
250 260 270 280 290
FVFKVLQEFY RYYKSNGTER WLAFFMWLNV SMLVFIIIPV IDKWNFLFIH HN