Q6MMA3

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)
KEGG Pathway
bba:Bd1733
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

516-603 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6MMA3

Entry ID Method Resolution Chain Position Source
AF-Q6MMA3-F1 Predicted AlphaFoldDB

No variants for Q6MMA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6MMA3

No associated diseases with Q6MMA3

7 regional properties for Q6MMA3

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 14 - 25 IPR001412
domain tRNA-binding domain 585 - 687 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 548 - 687 IPR004495
domain Methionyl/Leucyl tRNA synthetase 7 - 392 IPR015413
domain Methioninyl-tRNA synthetase core domain 6 - 368 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 381 - 392 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 378 - 515 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDKRKILIT CALPYANGYI HLGHLVEYLQ ADFWARFQNM RGNECVFICA DDTHGTPIMV
70 80 90 100 110 120
KARELGITPE ALIAQSYKEH TQDFADFQVQ FSHFGSTNSE ENRLLCEYFY KKMQEGNHTR
130 140 150 160 170 180
SQPIQQMYCN HDKMFLPDRF VKGTCPKCGA KEQYGDSCDV CASTYSPSDM KDVHCSLCGT
190 200 210 220 230 240
APVMKDSESI FFKLNDFKQY LEEWIPKHCS PEISKKMLEW FNEDLKDLDI SRDEPYFGFA
250 260 270 280 290 300
IPGTNNKKFF YVWVDAPMGY MSTTEQWAKS QGKTLKDIWQ DPSREIYHFI GKDIARFHTI
310 320 330 340 350 360
FWPAFLKAAE FRSPNQVFVH GHLMVNGEKM SKSKGTFIAA RTYLNHLNPE YLRYYYSTKL
370 380 390 400 410 420
SSSVDDIDLN LEDFTNRVNS ELVGKITNLG SRGGQMLKKK MDGKMSVPDA EGKKLIEHAQ
430 440 450 460 470 480
KTAESIAAHY EARDFAKALG EIRGLADDAN KYFDEKAPWK TLEADPEGTK QVITTTLNMF
490 500 510 520 530 540
RMLAIYLKPV LPFYSQKVAK LLGEKDYVWS DLNTVLTNRE INDYEHLATR IEADKVKAMV
550 560 570 580 590 600
EEGRKINEEI QAAKKAASTA KPAAAPAPAA AATAGDRPAE IEFADFDKVD LRIGQVIEAE
610 620 630 640 650 660
EIKEADKLLR LKIDIGEGQI RQIISGIKAA YKPEQLVGRK VLVCVNLKPR KMKFGMSEGM
670 680
VLAAGTGGSD LFVLSADDGA QVGQRVK