Q6MM37
Gene name |
kynA |
Protein name |
Tryptophan 2,3-dioxygenase |
Names |
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase |
Species |
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) |
KEGG Pathway |
bba:Bd1810 |
EC number |
1.13.11.11: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6MM37
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6MM37-F1 | Predicted | AlphaFoldDB |
No variants for Q6MM37
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6MM37 | |||||
No associated diseases with Q6MM37
5 regional properties for Q6MM37
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (D/K/N) | 162 - 501 | IPR004364 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 68 - 146 | IPR004365 |
| domain | Aminoacyl-tRNA synthetase, class II | 184 - 503 | IPR006195 |
| domain | Lysyl-tRNA synthetase, class II, C-terminal | 177 - 503 | IPR018149 |
| domain | Lysine-tRNA ligase, class II, N-terminal | 67 - 174 | IPR044136 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.11 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| metal ion binding | Binding to a metal ion. |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tryptophan catabolic process to kynurenine | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKYPPVHYHD | YLGLNPLLNA | QHPKSTEYGK | PAHDELLFII | VHQTYELWFK | QILFELDSVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STFQKPTVAE | SEMGIASARL | ERIVSILKLI | IGQVDVLETM | TPLDFLDFRD | MLYPASGFQS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQWRLIETKL | GLRIGDRLAY | NQSPFYKSLS | ESQQGEMLNI | MNQPSLHDSV | EKWLERTPFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QGENFNFWDS | YKEAVNKMFQ | DDITTVKNNP | RLPDEEKAKT | VAGLEQTLKS | FDALFDEEAF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKLRAEGQFR | LSYKAMHAAL | LIQLHRDQPI | LQTPFRIIRA | LLDIDETMTT | WRYRHALMAM |
| 310 | 320 | 330 | 340 | 350 | |
| RMLGQKIGTG | GSSGHKYLAD | ATAKHKIFGD | FFNLTTFFIP | RSQVPPLPKA | IADRMSFHY |