Q6MB06

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Protochlamydia amoebophila (strain UWE25)
KEGG Pathway
pcu:PC_RS07295
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-255 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6MB06

Entry ID Method Resolution Chain Position Source
AF-Q6MB06-F1 Predicted AlphaFoldDB

No variants for Q6MB06

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6MB06

No associated diseases with Q6MB06

4 regional properties for Q6MB06

Type Name Position InterPro Accession
domain DHHA1 domain 730 - 868 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 10 - 551 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 6 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLTQSIRRQF LEYFKKHQHQ IVSSSSVLPH DDPTLLFNNA GMNQFKDVFL GKSYRDYNRA
70 80 90 100 110 120
ATSQKCIRVG GKHNDLENVG HTSRHLTFFE MLGNFSFGDY FKTQAIRFAW EVSTQVFGFE
130 140 150 160 170 180
PERIWPTVFR EDDETFELWT QYVPAERITR FGEKDNFWAM GDTGPCGPCS ELLYDRGSDY
190 200 210 220 230 240
GNATKPSEDS SGERFLEFWN LVFMQFNRQT SGVQNPLPKP SIDTGAGLER VINLKMGVNS
250 260 270 280 290 300
VFETDILRSI IAQIELLSGI AYHPQDQQSA AFRVIADHLR CLSFAIADGV QPSNVDRGYV
310 320 330 340 350 360
LRKVLRRAVR YGRTLKLEKP FLAEVLPQLV STMGSDYPEL VKGQDRIAEI LTIEEEAFIR
370 380 390 400 410 420
TLKRGGNILN QVIEKSRASH QIISGDDAFK LKDTYGLPIE EILLIAKDSG LKVDEPRYQQ
430 440 450 460 470 480
LEEEAKQRSR HVHKTVHQIA GENIFADFVK VRGETKFAGF TQNSLKSSVV GLFVNGEFVE
490 500 510 520 530 540
EMQSGQEGLV FLSETPFYAE MGGQVGDTGT LENSNSKFSV EDCVVPYKGL IAHKGKLNTG
550 560 570 580 590 600
SLKNGEMITA SIDKKRRQKI ANNHTATHLL HWALHQILGE HIKQAGSVVD PQRLRFDFSH
610 620 630 640 650 660
HKALSLEESR QIEDLVNQKI RENLPVKCYE IKYEEAQKKE DIKQFFGEKY GSTVRVIDID
670 680 690 700 710 720
YSKELCGGTH TSALGNIGLF RILKESGIAA GIRRIEAVTG AEAELLQRQD EDLLRTLAQQ
730 740 750 760 770 780
LKVPIHQVLE KLEKLQEENK QFIAELKEIK KKELNVLING FIKKIEQLGN TSVLILETAL
790 800 810 820 830 840
SVEELRLCVD LISDQIPSAV IILGAAFPDK CQILVKISDD LVKQGINANE IIKILMPIVE
850 860 870
GSGGGKQHTA QGGGKKPAML GEAFKQIRIY LKEKMNVK