Q6LUL1

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Photobacterium profundum (strain SS9)
KEGG Pathway
ppr:PBPRA0591
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

808-894 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6LUL1

Entry ID Method Resolution Chain Position Source
AF-Q6LUL1-F1 Predicted AlphaFoldDB

No variants for Q6LUL1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6LUL1

No associated diseases with Q6LUL1

5 regional properties for Q6LUL1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 58 - 69 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 28 - 651 IPR002300
domain Zinc finger, FPG/IleRS-type 916 - 942 IPR010663
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 696 - 857 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 651 - 837 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKDTLNL PETGFPMRGN LAQREPVMLK RWDDEDLYGE IRKAKKGNKS FILHDGPPYA
70 80 90 100 110 120
NGDIHIGHAL NKILKDIIIK SKTLSGFDAP YIPGWDCHGL PIELMVEKKW GKPGRKLTAA
130 140 150 160 170 180
EFRQKCREYA AGQVEGQKES FIRLGVLGQW DKPYRTMDFA TEANIIRSLG KVAENDHLLK
190 200 210 220 230 240
GFKPVHWCTD CGSALAEAEV EYQDKVSPSI DVKFKAVDEA GVVAKFNCAE GHEGQGDVSV
250 260 270 280 290 300
VIWTTTPWTM PANRAVAVRD DLEYVLVQVE ADAANDKAAY RLIVAAELAK DVMDRAGIEH
310 320 330 340 350 360
FHNLGFCKGA DLELMRFNHP FYSFDVPIVL GDHVTTESGT GCVHTAPGHG QEDFVVGQKY
370 380 390 400 410 420
GLEIANPVGS NGVYLPDTEL FAGQHVFKAN DVVVETLKEH GALLHHHAYE HSYPHCWRHK
430 440 450 460 470 480
TPIIFRATPQ WFISMDKAGL RAKALGEIKN VQWLPEWGQS RIEGMVEGRP EWCISRQRTW
490 500 510 520 530 540
GVPIALFVHK ETQELHPDTR VLIEKVAQLV EQKGIQAWWD LNPAELMGEA DAANYEKVLD
550 560 570 580 590 600
TLDVWFDSGV THFSVVDSRE EYNGHSADLY LEGSDQHRGW FQSSLVSSVA MKGKAPYNQV
610 620 630 640 650 660
LTHGFVVDGQ GRKMSKSVGN VVAPKDVTNK LGADILRLWV ASTDYTGEVA VSDEILKRSA
670 680 690 700 710 720
DAYRRIRNTA RFFLANLNGF NPETDLVAPE EMVALDRWAV GRAMEAQEEI IKAYDGYNLH
730 740 750 760 770 780
GVTQRLMQFC SVEMGSFYLD VIKDRQYTAK QGGHAQRSCQ TALFYIVEAL VRWMAPIMSF
790 800 810 820 830 840
TADEIWNEMP ASQGNGEQRD KFVFTGEWFE GLFGLADDEV MNDEFWAEIQ QVRGAVNKLL
850 860 870 880 890 900
ELARKDKVIG GSLQAEITLH ANETLAAKLN TLEDELRFVL LTSKAAVAIT DSMPEGAQKT
910 920 930 940 950
DVEGLFVTVN ASEAAKCDRC WHHVADVGTI EGHEEVCGRC VTNISGEGEE RKFA