Q6LA55

PR
Gene name
SPAC3H5.09c
Protein name
UPF0648 protein C3H5.09c
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3H5.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

961-1033 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6LA55

Entry ID Method Resolution Chain Position Source
AF-Q6LA55-F1 Predicted AlphaFoldDB

26 variants for Q6LA55

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3416777_C_T 19 S>L No Jeffares_SNPs
I_3416836_C_T 39 L>F No Jeffares_SNPs
I_3416869_T_C 50 F>L No Jeffares_SNPs
I_3417160_T_A 147 L>I No Jeffares_SNPs
I_3417192_G_C 157 Q>H No Jeffares_SNPs
I_3417464_A_T 248 Y>F No Jeffares_SNPs
I_3417564_T_A 281 F>L No Jeffares_SNPs
I_3417605_C_T 295 S>F No Jeffares_SNPs
I_3418105_A_G 462 T>A No Jeffares_SNPs
I_3418108_T_C 463 S>P No Jeffares_SNPs
I_3418221_T_G 500 F>L No Jeffares_SNPs
I_3418510_C_T 597 L>F No Jeffares_SNPs
I_3418525_T_C 602 S>P No Jeffares_SNPs
I_3419006_C_T 762 S>F No Jeffares_SNPs
I_3419030_A_G 770 N>S No Jeffares_SNPs
I_3419121_C_G 800 D>E No Jeffares_SNPs
I_3420301_T_C 1194 S>P No Jeffares_SNPs
I_3420505_C_A 1262 L>M No Jeffares_SNPs
I_3421349_C_T 1543 S>L No Jeffares_SNPs
I_3422042_G_C 1774 S>T No Jeffares_SNPs
I_3422222_C_T 1834 S>L No Jeffares_SNPs
I_3423328_C_T 2203 H>Y No Jeffares_SNPs
I_3423514_G_C 2265 E>Q No Jeffares_SNPs
I_3424488_A_T 2589 E>D No Jeffares_SNPs
I_3424574_C_T 2618 A>V No Jeffares_SNPs
I_3424616_C_T 2632 P>L No Jeffares_SNPs

No associated diseases with Q6LA55

6 regional properties for Q6LA55

Type Name Position InterPro Accession
domain FMP27, sixth RBG unit 827 - 975 IPR019409
domain FMP27, SW motif-containing RBG unit 1053 - 1156 IPR019415
domain FMP27/BLTP2, N-terminal 33 - 809 IPR019439
domain FMP27/BLTP2/Hobbit, GFWDK motif-containing RBG unit 1174 - 1330 IPR019441
domain BLTP2/FMP27/Hobbit, C-terminal 2089 - 2547 IPR019443
domain FMP27, WPPW motif-containing RBG unit 1588 - 2074 IPR019449

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
protein-membrane adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.

1 GO annotations of biological process

Name Definition
endoplasmic reticulum-plasma membrane tethering The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPLFPFSLL NPSTMWSSSQ NTSFVWVVIA TGFLFHLVLF VLSYVLGWPF TNFGFFSVYG
70 80 90 100 110 120
LRHTFRNGDS VFISYVALRL HRPSTSKPYL LRIVTKGLIY TPSLSSANDA QSAGKNENQR
130 140 150 160 170 180
SRLVFKAKRE EEKTEEKFCH AVYMSNLLRN VEQKWIQFLH KSWMKWLHIS IQESQLTFPS
190 200 210 220 230 240
VGTFELGSLS MEMRPETNNV VGYENPSDPE LVSSCVICSI RLANLVYIDR RQSSQQITDY
250 260 270 280 290 300
LDLSLQTYYS LDKSNVPDTI LRLRSSIKVG VLYIDLDTPL FEHLLNSNSS GGNHSSSSSS
310 320 330 340 350 360
SGKVHVMKDN VEAALLKLQE AQIQIGTLKL WKRNVTGCGA TYILNGSDFG LNLILLNKKN
370 380 390 400 410 420
PSHRMFFPVE ACVHQILASA LSFNVESITP GHSPHVLLNI PLVTITCLTS ALAEYARDAS
430 440 450 460 470 480
DLHQLQNSIL RVNSTLTSPS LDLRLELLHD VLSCFPKKHD STSRKKPKFP YQYFPYMKFS
490 500 510 520 530 540
VSLYEPALRF LIASKSDSDF PGMLVANLSS MFLDIKYSPS SEHIFEIESS LRLSSNKVFY
550 560 570 580 590 600
HNPKNKKWLI NTSDLITFSL GYICNNDHGS LNMFFRDFQI RIEEEEVINS LKKFIILTKI
610 620 630 640 650 660
KSEQVGPRKP RTKLVEPLLF RIPKWLKHIQ LEVHSLLLVI TAIRPEISPE PRGINCSIDK
670 680 690 700 710 720
IHSLYLNDKK SRSQGMRKFD LNLELLMIKS IIFKNGKSLN SHLFLQIPNI NFIVSTILRD
730 740 750 760 770 780
NTAISRFTTE INFLRCFASL LHNCCIFYAY RACSSLFGEN KSHKRIEKTN TSPQEPGVVP
790 800 810 820 830 840
EGWNFDFRLK NARVSIFLDD DVSLLLDCGG FTTLKKTEKK YAEMHAKFIQ IHTKNSDVPT
850 860 870 880 890 900
LWDRFLALGN VRYQLKDLSD LEKLHQVTCS YISIRIPHKF IPFILIESAI NTVKAAIRVS
910 920 930 940 950 960
AEPLTIDQQH DLAEEIKQPR VVPHIQIKST KFKFEVDDDP FECRLGMNYR IGLTEQQMRI
970 980 990 1000 1010 1020
DRWNIFEERA NLLRKAKDPS PKSASESSSF YQNGSDIDDN DSNSSNTSNH TTENANAQQR
1030 1040 1050 1060 1070 1080
KLEDLNRSFE DFLGSRPTNN SSFLKNVSVD EDTAREKLME YDSLSWISNI KRIREFRYHR
1090 1100 1110 1120 1130 1140
LRIRRMTAWP ESDALDKHIL FKENIIPIPI RPPLVDISLL NFDFTLDKPS FPLEELPKFL
1150 1160 1170 1180 1190 1200
NTVGRGQPLD YGYSIYFPMY IDWKMDEAKF LIRDYPLPLV YIPKLGRGQD KRISSWHLKS
1210 1220 1230 1240 1250 1260
NMVITEQQAT LAAIRDVSVK VIPADLTKEG IPYVVNVTRT VSPIKTFSKT EIDVNSSLPT
1270 1280 1290 1300 1310 1320
FLLWCNSYQP ALSDMTRIMD TFTKMPIDPS EKLGFWDKIR LVAHSQIRLR WLEDGDVFLS
1330 1340 1350 1360 1370 1380
LKGSRDPYVI LGEGAGFQFC WSGNVSWDIG CDENPANFMI VDSDKFYLTI PDFPRQINGI
1390 1400 1410 1420 1430 1440
LEGKPLPTKS TKRSYTTFGV LKDLRCRKVI AKLVGKVRWR AGFVPERHCD EDCTVCNRKK
1450 1460 1470 1480 1490 1500
ACRLWNFKPH WQVITRIPQY CHDTHYGVYD AYRDFRSHYI HCSLALESPR YLDDANAFEN
1510 1520 1530 1540 1550 1560
VNSYNTIHLT PLVFSHFSSW WNLFSNNMSY PLRSGNLFPT LDSSPNKKFG RHLATFKYAL
1570 1580 1590 1600 1610 1620
ELTPLFISHM YNYKTNKNWQ DRTASATGLK ARVDNFTIDL HQRSEKHEVK NKANLGRKHQ
1630 1640 1650 1660 1670 1680
EATSMKVHLA EIDFKTIDLR AISASFDEGA LDNSDSIPAN VLDEEEKECF SFKNVDGPAN
1690 1700 1710 1720 1730 1740
WVDIDDYHEA DWLLPQQNEK CSIYPLAFSP RFTYYRHTKC HRRNEKNEKE IIPDTCRFGD
1750 1760 1770 1780 1790 1800
EFTHRCLMPS RENPKAVQYE LLQKRRKELE EFMSSEQERI GFLKSQLESN NDSEEVRQEY
1810 1820 1830 1840 1850 1860
EELTKRIVTL SDHYRLLEYL LKDESSCSQA SQCSENGQVD LSYASLSESV HAFNNRFVAH
1870 1880 1890 1900 1910 1920
NVQVKWNNFI RNAVMSYVHE VERVRGFAYY MSQKAIVFLR DLEKRTESAN DDFFGNYTED
1930 1940 1950 1960 1970 1980
DEDRENARHL LKFLLEDSKK RFWVKTSDAD REHGSEEGNT NSISNNEYDI IQSYVFRFIS
1990 2000 2010 2020 2030 2040
PQIQLQCSSN PEKAVIISIQ SLQIKILSVV DPIFPDNDIN YLIERRFLCK VNESQFFISK
2050 2060 2070 2080 2090 2100
KSDFEVVNAS SLVLNEYGCE HNTVWPPWVP FETTFDFVLT PAAFSRFLHR VSFSVIYTKH
2110 2120 2130 2140 2150 2160
NDLRLQETVH STRAFFEDLD THADTLTFDF PRVVFSTDSS QYYDIFTIIT DLLLYKEPAQ
2170 2180 2190 2200 2210 2220
KQRNQRLEEI MLAADFSDLT GTSEVVRALQ ARVHRLLDLK LQHQLYDVTF GIYAHIAQQL
2230 2240 2250 2260 2270 2280
FLQNELHRCG EELYYLIESI AAVQNRGIHQ NKVRSNLSWF LMAKEVVWHL LEDNKKPFLD
2290 2300 2310 2320 2330 2340
VRLQNATFRR IENSDASNFN TLEIEFMKGS NLAPGCQFEN IICPYFNHEF SNEQLLQQKF
2350 2360 2370 2380 2390 2400
IRIHWEVLEA VAGIQVIQHF EINLFPLSLQ IEQELATKLF AYAFPNRNES DGFPHIYSRN
2410 2420 2430 2440 2450 2460
HDKRKENGSQ GEADNSNYSG SLMRRRTNDQ EEDALATPSS SRRDSRSKRA SLIDFTIDKC
2470 2480 2490 2500 2510 2520
LDVDDEGRME LQSMLDRAGS NMLITYFKIP SVVLRLSYRG TGGLGLENIT GFVFTVPTME
2530 2540 2550 2560 2570 2580
YRNEVCSYLD LAMKLKHDLI RTVVSHTGKL LVEKVKGNYH LKEHEREVSS ELLNLQQLSA
2590 2600 2610 2620 2630 2640
EHNRHADLES MVMARDDYIN VQQPLAEENQ EEGSPASAIS RNHSTRSSLN SPRQFWAYHG
2650 2660 2670 2680 2690
SRSKKIADIV KRHIPPTING KRSKNKGNEG SNARVDFYND ERYDPVKREL ILGASNRRK