Q6L8K7

PR
Gene name
PAT1 (YALI0E11099g)
Protein name
Acetyl-CoA acetyltransferase
Names
Peroxisomal acetoacetyl-CoA thiolase, Thiolase
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0E11099g
EC number
2.3.1.9: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

186-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6L8K7

Entry ID Method Resolution Chain Position Source
AF-Q6L8K7-F1 Predicted AlphaFoldDB

No variants for Q6L8K7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6L8K7

No associated diseases with Q6L8K7

4 regional properties for Q6L8K7

Type Name Position InterPro Accession
conserved_site Thiolase, conserved site 341 - 357 IPR020613
active_site Thiolase, acyl-enzyme intermediate active site 91 - 109 IPR020615
domain Thiolase, N-terminal 12 - 263 IPR020616
domain Thiolase, C-terminal 274 - 392 IPR020617

Functions

Description
EC Number 2.3.1.9 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLTLPRLNA AYIVGAARTP VGKFNGALKS VSAIDLGITA AKAAVQRSKV PADQIDEFLF
70 80 90 100 110 120
GQVLTANSGQ APARQVVIKG GFPESVEATT INKVCSSGLK TVALAAQAIK AGDRNVIVAG
130 140 150 160 170 180
GMESMSNTPY YSGRGLVFGN QKLEDSIVKD GLWDPYNNIH MGNCCENTNK RDGITREQQD
190 200 210 220 230 240
EYAIESYRRA NESIKNGAFK DEIVPVEIKT RKGTVTVSED EEPKGANAEK LKGLKPVFDK
250 260 270 280 290 300
QGSVTAGNAS PINDGASAVV VASGTKAKEL GTPVLAKIVS YADAATAPID FTIAPSLAIP
310 320 330 340 350 360
AALKKAGLTK DDIALWEINE AFSGVALANL MRLGIDKSKV NVKGGAVALG HPIGASGNRI
370 380 390
FVTLVNALKE GEYGVAAICN GGGASTAIVI KKVSSVE