Q6L0J9
Gene name |
hemA |
Protein name |
Glutamyl-tRNA reductase |
Names |
GluTR |
Species |
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) |
KEGG Pathway |
pto:PTO0918 |
EC number |
1.2.1.70: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6L0J9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6L0J9-F1 | Predicted | AlphaFoldDB |
No variants for Q6L0J9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6L0J9 | |||||
No associated diseases with Q6L0J9
4 regional properties for Q6L0J9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | 162 - 276 | IPR006151 |
| domain | Glutamyl-tRNA reductase, N-terminal | 33 - 139 | IPR015895 |
| domain | Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain | 294 - 381 | IPR015896 |
| conserved_site | Glutamyl-tRNA reductase, conserved site | 82 - 105 | IPR018214 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.1.70 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutamyl-tRNA reductase activity | Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protoporphyrinogen IX biosynthetic process | The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIIMIPIYAI | TWNFRDTPEG | FDKIVNNDYN | YFESLCKKSS | IDEFVILITC | NRVEIYAYTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NEIDKDLFKD | SLIYNYPEST | MHLLRVASGL | ESMSIGENDI | MRQVKEAYEL | SIKRKTSGKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSYIFKKALN | VGKEVRTQTS | ISRGKTSIPA | ISLDICDNEY | GINNKSILII | GNGKMATDFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RYLKEYRPGN | VTIAGRSIDH | ARNLAVLYGY | SYDSIKNLNN | LIKNSDIIIA | ATSAGNYIVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLGDLARNKY | FIDISKPENI | DPEISKYARL | LSINEIGKIL | KRNEDEKKGE | VEIAEVIINQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EQKTIDEKLK | EMMLDDVIAM | FYKFANNVKK | DELEELFLIQ | DFNDEQKKDI | DAMTSSLINK |
| 370 | 380 | 390 | 400 | ||
| ILAPYTNSVK | QFIKENKNFD | YILNEYKKML | EQFMENIVKK | L |