Q6GQD0
Gene name |
ncbp1-b |
Protein name |
Nuclear cap-binding protein subunit 1-B |
Names |
|
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:443898 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GQD0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GQD0-F1 | Predicted | AlphaFoldDB |
No variants for Q6GQD0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6GQD0 | |||||
No associated diseases with Q6GQD0
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRRRHSDEN | DGGQPHKRRR | TSEPLEIEDR | LESLICRVGE | KSTSSLESNL | EGLAGVLEAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPNYKNKILR | ILCFVARLLP | EKMTVYTTLV | GLLNARNYNF | GGEFVEAMIR | HLKETIKLNA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YNEAIYLVRF | LCDLVNCHVI | AAPSMVAMFE | SFVGVTQEED | IPQVRSDWYV | YAVLSSLPWV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKELYEKKDV | EMDQILSQIE | AYLKQRQKLH | LSILQVWSAE | KPHPQEEYLD | CLWAQVQKLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDRWQERHIQ | RPYLAFDSVL | CEALQHNLPP | FTPPPHTEDS | VYPVPRVIFR | MFDYTDAPEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVMPGSHSVE | RFVIEENLHC | ILKSHWRERK | TCAAQLLSYP | EKNKIPLNYH | IVEVIFGELF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLPSPPQIDV | MYTTLLIELC | KLQPGSLPQV | LAQASEMLYT | RLDTMNTTCI | DRFINWFSHH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LSNFQFRWNW | EDWADCLSQD | LDKPKPQFVR | EVLEKCMRLS | YHQRILDIVP | ATFSALYPAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSNVIKYGDE | SNSALPGYSV | AVILTNAIKN | KASDKEIFNI | LKDIPNPNQD | DYDDEGIGFN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PLKIEVFVQT | LLNLASKSFS | HSFSALAKFH | DIFKALSESD | EGKLHILRVV | YDVWKNHPQM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IAVLLDKMIR | TQIVDCAAVA | NWIFSPELSP | DFTRFYIWEI | LHSTIRKMNK | HVQKIQKELE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DTKQRLAKQH | KHRDSDDNDE | DSGRKDGPLE | EQIERLQEKV | ESAQSEQKNL | FLVIFQRFIM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ILTEHLVRCE | TGGIDVNTAW | YKNCRERLQQ | IFLQHHQTIQ | QYMVTLENLL | FTAELDHHIL |
| 790 | |||||
| TVFQQFCALQ | S |