Q6GQA6

PR
Gene name
csn8
Protein name
COP9 signalosome complex subunit 8
Names
Signalosome subunit 8
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:443917
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GQA6

Entry ID Method Resolution Chain Position Source
AF-Q6GQA6-F1 Predicted AlphaFoldDB

No variants for Q6GQA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GQA6

No associated diseases with Q6GQA6

2 regional properties for Q6GQA6

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 10 - 183 IPR000717
domain CSN8/PSMD8/EIF3K 35 - 168 IPR033464

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
COP9 signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLSESVMAQ NSVSFQKLQE QCEEQELEAP GGIASPQVYN QLLALYLLHN DLNNARYLWK
70 80 90 100 110 120
RIPSAIKSSH SELGGIWEVG QKIWQRDFPG IYTSISAYQW SENIQQIMEA VRDATQQRAF
130 140 150 160 170 180
GLVSQAYTSI SADDFAAFVG LPVEEAVKGV LEQGWQADSA TGMVMPKKPD SAPLSLIPNE
190
QQLARLTDYV AFLEN