Q6GQ81

PR
Gene name
mief2 (mid49, smcr7)
Protein name
Mitochondrial dynamics protein MID49
Names
Mitochondrial dynamics protein of 49 kDa homolog, Mitochondrial elongation factor 2, Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:443935
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GQ81

Entry ID Method Resolution Chain Position Source
AF-Q6GQ81-F1 Predicted AlphaFoldDB

No variants for Q6GQ81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GQ81

No associated diseases with Q6GQ81

1 regional properties for Q6GQ81

Type Name Position InterPro Accession
domain Mab-21-like, HhH/H2TH-like domain 359 - 444 IPR046906

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
dynamin family protein polymerization involved in mitochondrial fission The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission.
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAELQIRKKE KKSGDGIGTM VDFLLANARL VLGVGGAAML GIATLAVKRL IDRATSPPSD
70 80 90 100 110 120
KEAEEKAEQK SIEESWKEAV LKKASPTLRR KEDLEHHCAP LSLPDPSQKM PEATGTSQVK
130 140 150 160 170 180
ASDEIKKIPI CFTLQERLLN YHTHHASVPE VQMEEARQLV LDIKKELQEF LHAKHPEMPF
190 200 210 220 230 240
LALHLGGSFG NRLPMSCLDH ACLIMPLVLE PDLWCVIPGQ KTILSDPNFC MVKRIDLEYT
250 260 270 280 290 300
SRGSSPWDRF LVGAYLSSRT MVQSLHKTIV GSINWPAIGT VLDCTIKPDI TSDELKLEVV
310 320 330 340 350 360
HPNGHMIIRI LPMAVIKDAD LLAHCCATAP AENLWQRSFY KKEVSRLQEL DSSDSGIRLK
370 380 390 400 410 420
CLQILKGICR DCPSLCHLNS THLRHILLHL STESSDWTET ALADRFLQVL EELIGYLDKG
430 440 450 460
FLPSYFNDKL NLFSSLKAED IEELGYGLYQ VFSEPDDVLK RER