Q6GQ80

PR
Gene name
ncbp1-a
Protein name
Nuclear cap-binding protein subunit 1-A
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:443936
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GQ80

Entry ID Method Resolution Chain Position Source
AF-Q6GQ80-F1 Predicted AlphaFoldDB

No variants for Q6GQ80

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GQ80

No associated diseases with Q6GQ80

2 regional properties for Q6GQ80

Type Name Position InterPro Accession
domain RNA recognition motif domain 37 - 115 IPR000504
domain NCBP2, RNA recognition motif 39 - 116 IPR034148

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear cap binding complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.

6 GO annotations of biological process

Name Definition
7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRRRHSDEN DGGQAHKRRK TSEPLEIEDR LESLICRVGE KSTSSLESNL EGLAGVLEAD
70 80 90 100 110 120
LPNYKSKILR ILCFVARLLP EKMSVYSTLV GLLNARNYNF GGEFVEAMIR HLKETIKLNA
130 140 150 160 170 180
YSEAVYLVRF LSDLVNCHVI AAPSMVAMFE SFVGVTQEED IPQVRSDWYV YAVLSSLPWV
190 200 210 220 230 240
GKELYEKKDV EMDRILSQIE AYLKQRQKLH VSILQVWSAE KPHPQEEYLD CLWAQIQKLK
250 260 270 280 290 300
KDRWQERHIL RPYLAFDSVL CEALQHNLPP FTPPPHTEDS VYPVPRVVFR MFDYTDAPEG
310 320 330 340 350 360
PVMPGSHSVE RFVIEENLHC ILKSHWRERK TCAAQLLSYP EKNKIPLNYH IVEVIFGELF
370 380 390 400 410 420
QLPTPPHIDV MYTTLLIELC KLQPGSLPQV LAQASEMLYT RLDTMNTICI DRFINWFSHH
430 440 450 460 470 480
LSNFQFRWNW EDWADCLSQD LNKPKPQFVR EVLEKCMRLS YHQRILDIVP ATFSALYPAS
490 500 510 520 530 540
PSCVFKYGDE SNSALPGYSV AVTLTNEIKN KASDKEIFNI LKDIPNPNQD DDDDEGISFN
550 560 570 580 590 600
PLKIEVFVQS LLNLASKSFS HAFSALAKFH DIFKALSESD EGKLHILRVA YDVWKNHPQM
610 620 630 640 650 660
IAVLVDKMIR TQIVDCAAVA NWIFSPELSH DFTRFYIWEI LHSTIRKMNK HVQKIQKELE
670 680 690 700 710 720
ETKQRLAKQH KHRDSDDNDE DSGRKDGPLE EQIERLQEKV ESAQSEQKNL FLVIFQRFIM
730 740 750 760 770 780
ILTEHLVRCE TGAIDVNTAW YKNCRERLQQ IFLQHHQTIQ QYMVTLENLL FTAELDHHIL
790
TVFQQFCALQ S