Q6GPL3

PR
Gene name
aurkb-b (airk2-b)
Protein name
Aurora kinase B-B
Names
Aurora/IPL1-related kinase 2-B, AIRK2-B, XAIRK2-B, Serine/threonine-protein kinase 12-B, Serine/threonine-protein kinase aurora-B-B, xAurora-B-B
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:444083
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

240-261 (Activation loop from InterPro)

Target domain

100-350 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6GPL3

Entry ID Method Resolution Chain Position Source
AF-Q6GPL3-F1 Predicted AlphaFoldDB

No variants for Q6GPL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GPL3

No associated diseases with Q6GPL3

3 regional properties for Q6GPL3

Type Name Position InterPro Accession
domain Protein kinase domain 100 - 350 IPR000719
active_site Serine/threonine-protein kinase, active site 219 - 231 IPR008271
binding_site Protein kinase, ATP binding site 106 - 129 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Chromosome
  • Chromosome, centromere
  • Cytoplasm, cytoskeleton, spindle
  • Midbody
  • Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis
  • Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity (H3-S10 specific) Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.
histone kinase activity (H3-S28 specific) Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

15 GO annotations of biological process

Name Definition
abscission The controlled shedding of a body part.
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
mitotic cytokinesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
negative regulation of B cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
negative regulation of cytokinesis Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of mitotic sister chromatid segregation Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
protein phosphorylation The process of introducing a phosphate group on to a protein.
spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYKENLIPS SCSSSSSSSS KFATPSSATA AQRVLRKQPY VSIFTTPSDN LLAQRAQLAP
70 80 90 100 110 120
RVTPAASSSV PGRVALGTDV ASHNTALAEA PKRKFTIDDF DIGRPLGKGK FGNVYLAREK
130 140 150 160 170 180
QNKFIMALKV LFKSQLEKEG VEHQLRREIE IQSHLRHPNI LRMYNYFHDR KRIYLMLEFA
190 200 210 220 230 240
PRGELYKELQ KHGRFDEQRS ATFMEELADA LQYCHERKVI HRDIKPENLL MGYKGELKIA
250 260 270 280 290 300
DFGWSVHAPS LRRRTMCGTL DYLPPEMIEG KTHDEKVDLW CAGVLCYEFL VGMPPFDSPS
310 320 330 340 350 360
HSETHRRIVN VDLKFPPFLS EGSKDLISKL LRYHPAQRLP LKGVMEHPWV KANSRRVLPP
VYQSSHPK