Q6GNV5

PR
Gene name
fnbp1
Protein name
Formin-binding protein 1 homolog
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:444253
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

120-210 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GNV5

Entry ID Method Resolution Chain Position Source
AF-Q6GNV5-F1 Predicted AlphaFoldDB

No variants for Q6GNV5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GNV5

No associated diseases with Q6GNV5

5 regional properties for Q6GNV5

Type Name Position InterPro Accession
domain FCH domain 1 - 94 IPR001060
domain SH3 domain 543 - 604 IPR001452
domain HR1 rho-binding domain 397 - 474 IPR011072
domain F-BAR domain 1 - 264 IPR031160
domain Formin-binding protein 1, F-BAR domain 5 - 257 IPR037449

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cell cortex
  • Lysosome
  • Cytoplasmic vesicle
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Membrane, clathrin-coated pit
  • Enriched in cortical regions coincident with F-actin
  • Also localizes to endocytic vesicles and lysosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
clathrin-coated pit A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

2 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWGTELWDQ FDNLEKHTQW GIEVLEKYIK FVKERAEIES NYAKQLRNLS KKYQTKKNSK
70 80 90 100 110 120
EEEESKYTSC KAFQTTLNEM NDYAGQHEVI SENAASLITV ELTRFVQELK QERKQHFHEG
130 140 150 160 170 180
RKAQQQIETC WKQLEASKRR FERDCKEAER AQQHFEKMDA DINVTKADVE KARQQAQIRH
190 200 210 220 230 240
QMSDDSKGDY SSVLQKFNRE QHEHYFTHIP GIFQKLQDME EKRIGRMGES LKTYADIDRQ
250 260 270 280 290 300
VVPIIGKCLD GITKSAESIS EKQDSQMVVE SFKSGFEPPG DIDFEDFTQN MKRTVSDTSL
310 320 330 340 350 360
TKADSKSDPK VPSKSRNKLW PFIKKNKLMS LLTSPHQPPP PPPASSSPSA VPNGPHSPKQ
370 380 390 400 410 420
QKEPLSHRFN DFMTSKPKMH CFRSLKRGGS TPEDFSNLPP EQRRKKLQQK VDELNKDIQK
430 440 450 460 470 480
EIDQRDALTK MRDVYTKNPQ MGDAASVGQK LVEIGNNIEK LRVEVQKFEG WLAEVEGRLS
490 500 510 520 530 540
ARNDSSRRQS GLYDTQNTQT VNNCAQDRES PDGSYTEDHS QEPEVKVTPT EFDDDFDDEE
550 560 570 580 590 600
PLPTIGTCKA IYPFDGENEG TISVTEGEIL KVIEEDKGDG WTRIRRSEED EGYVPTSYIE
VYLDRNAKDS