Q6GN16

PR
Gene name
pi4kb (pik4cb)
Protein name
Phosphatidylinositol 4-kinase beta
Names
PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:444446
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

677-699 (Activation loop from InterPro)

Target domain

517-804 (Catalytic domain of Type III Phosphoinositide 4-kinase beta)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6GN16

Entry ID Method Resolution Chain Position Source
AF-Q6GN16-F1 Predicted AlphaFoldDB

No variants for Q6GN16

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GN16

No associated diseases with Q6GN16

4 regional properties for Q6GN16

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 523 - 802 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 55 - 245 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 551 - 565 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 644 - 664 IPR018936-2

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endomembrane system
  • Mitochondrion outer membrane ; Peripheral membrane protein
  • Rough endoplasmic reticulum membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGDTMVEPVP VKLSDQSLVL RGNGGSALCV ITEGVGEASL VIDPDVAQKA CQEVLEKVKM
70 80 90 100 110 120
IHGSSVESLD KVDGGDAGDG GSLANGDTEP KLTNTGHTST SSRINEEESP LDINSVKNAR
130 140 150 160 170 180
RRQKNNSAKQ SWLLRLFECK LFDVSMAISY LYNSKEPGVQ AYIGNRLFCF RYEDVDFYLP
190 200 210 220 230 240
QLLNMYIHMD EDVGDAIKPY VVHRCRQSIN FSLQCAWLLG AYSSDMHIST QRHSRGTKLR
250 260 270 280 290 300
KLILSDELKP AHKKREIPPL SLAPDTGLSP SKRTHQRSKS DATVSISLSS NLKRTSSNPK
310 320 330 340 350 360
VENDDEPVRL APEREFIKSL MGIGKRLATL PTKEQKTQRL ISELSLLNHK LPARVWLPTA
370 380 390 400 410 420
GFDHHVVRVP HTQAVVLNSK DKAPYLIYVE VLECENFETS LVPVRIPENR IRSTRSVENL
430 440 450 460 470 480
PECGITHEQR ASSFTTVPNY DNDDEAWSVD DIGELQVELP ELHTNSCDNI SQFSVDSITS
490 500 510 520 530 540
QESKDPVFIA AGDIRRRLSE QLAHTPTTFR RDPEDPSAVA LKEPWEEKVR RIREGSPYGH
550 560 570 580 590 600
FPNWRLLSVI VKCGDDLRQE LLASQVLKQL QSIWESERVP LWIRPYKILV ISGDSGMIEP
610 620 630 640 650 660
VVNAVSIHQV KKQSQLSLLH YFLQEHGSCT TEAFLTAQRN FVQSCAAYCL VCYLLQVKDR
670 680 690 700 710 720
HNGNILLDAE GHIIHIDFGF ILSSSPRNLG FETSAFKLTA EFVDVMGGLN GDMFNYYKML
730 740 750 760 770 780
MLQGLIAARK HMDKVVQVVE IMQQGSQLPC FHGSSTIRNL KERFHMNMTE EQLQILVEQM
790 800
VDGSMRSITT KLYDGFQYLT NGIM