Q6GN11

PR
Gene name
dis3l
Protein name
DIS3-like exonuclease 1
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:444450
EC number
3.1.13.1: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

962-1040 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GN11

Entry ID Method Resolution Chain Position Source
AF-Q6GN11-F1 Predicted AlphaFoldDB

No variants for Q6GN11

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GN11

No associated diseases with Q6GN11

4 regional properties for Q6GN11

Type Name Position InterPro Accession
domain Ribonuclease II/R 459 - 809 IPR001900
conserved_site Ribonuclease II/R, conserved site 776 - 800 IPR022966
domain Rrp44-like cold shock domain 232 - 310 IPR033771
domain Dis3-like cold-shock domain 2 360 - 427 IPR041505

Functions

Description
EC Number 3.1.13.1 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

2 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKTEKILHL KTQRGRSVRA VREHYLREDV RCGSALCHTC PRDGKLLSEE LTHYVVPDCQ
70 80 90 100 110 120
VLQDYQEVLE FPELRGIIIM QTACQAVQHQ RGRRQYKKLC SLLRDTRHDC ILFSNEFQNH
130 140 150 160 170 180
AYLPREMGES ALAWQTRCIY NSCVWYYQHC QKKIPVVMVT EDESVIGKYN TETQEVYVVS
190 200 210 220 230 240
FQIYLETFWP NFKGALELYK SLRDTHLERK LESRESNGKE YPEHLPLEIL EAGIKSGRYK
250 260 270 280 290 300
QGVLSVNKHR AQLESFVRLQ GLGGKETDIQ SDIFIHGTKP RNRAIHGDLV AVELLPKSEW
310 320 330 340 350 360
KGRTGALCEN ETDEKVGDMQ AEVMPTGRVV GIMQRNWRDY VVTFPAKEDT ETQGKNTQKV
370 380 390 400 410 420
LVMPWDYRIP KIRISTQQAE ALQNYRVVVR IDSWESNSLY PNGHFVRALG RAGNLEAEIA
430 440 450 460 470 480
TILVENSISL NPFSEAQLAE MPSNTHENPW QVKPEEGDRL DLRETHLVFS IDPKGCEDVD
490 500 510 520 530 540
DALSIRVLPS GDLELGVHIA DVTHFVQHNT YTDIEARSRA TTYYLADRRN DMLPLILSAD
550 560 570 580 590 600
LCSLLGAVDR YAVSVIWEMD CSTYEIRRVW YGRTIIRSSY KLSYEVAQQL LDGDLEPLST
610 620 630 640 650 660
EKELHPLKQD PARLQQLLWA VGKMTEVAHA TRMRRNMSGA LELEGVEVRV QLGEKHSIDD
670 680 690 700 710 720
LVPKQPLQVH ETIAECMILA NHWVAKKIWE SYPQHALLRL HPPPRQEFFQ ELKECAKARG
730 740 750 760 770 780
FSIDTRSNKA LADSLDQAHD PSDPLVNQLL RMMATQAMSN ARYFSTGSYT EDEFYHYGLA
790 800 810 820 830 840
LEKYTHFTSP IRRYADIVVH RLLLAAVNKG PKDHLLGNKD LEELCRHINA RNRAAQQCQK
850 860 870 880 890 900
QSTELFQCMF FKDKDPDSDQ RCISDAVIYG IRTNGVLLFI PRYGIKGAAY LKNTDGLVLA
910 920 930 940 950 960
CEEDGQCRWV HGSLQRLPAQ IVVTTQEAKS FSFCLFDHVT VRIRIQSSRF HPDSIRLEII
970 980 990 1000 1010 1020
SNRPNPSQEA LPSASNPQLL RTELVKEVTR TAVEAQLAVE GAAELKPVER YQEYRQTQGQ
1030
SLYTMLEELW DLALLDVSGA