Q6GM82

PR
Gene name
gpt2
Protein name
Alanine aminotransferase 2
Names
ALT2, Glutamate pyruvate transaminase 2, GPT 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:444533
EC number
2.6.1.2: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GM82

Entry ID Method Resolution Chain Position Source
AF-Q6GM82-F1 Predicted AlphaFoldDB

No variants for Q6GM82

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GM82

No associated diseases with Q6GM82

1 regional properties for Q6GM82

Type Name Position InterPro Accession
domain Aminotransferase, class I/classII 143 - 528 IPR004839

Functions

Description
EC Number 2.6.1.2 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
L-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

4 GO annotations of biological process

Name Definition
2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
L-alanine metabolic process The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSILRGSLRG VLAPNASVVF RSRLPPQLTS ALLCPLRSLS GTPLAEPDGK VTRKMSENGT
70 80 90 100 110 120
CNRILTLDSM NPCIQKVEYA VRGPIVIRAV ELEKELQQGV KKPFTEVIKA NIGDAHAMGQ
130 140 150 160 170 180
KPVTFLRQVS AICLYPELMN DNKFPEDVKQ KAARILQACG GHSIGAYSAS QGIEVIRQDV
190 200 210 220 230 240
AKYIERRDGG ILSDPNNIYL STGASDSIVT MLKLLVSGQG KSRTGVMIPI PQYPLYSAAL
250 260 270 280 290 300
AELDAVQVNY YLDEENCWAL DINELRRALA EARKHCDPKV LCIINPGNPT GQVQSRKCIE
310 320 330 340 350 360
DVIRFAAEEN LFLMADEVYQ DNVYAKGCAF HSFKKVLFEM GPKYSETLEL ASFHSTSKGY
370 380 390 400 410 420
MGECGFRGGY MEVINMDPAV KQQLTKLVSV RLCPPVPGQV LLDVIVNPPK PGEPSYKQFI
430 440 450 460 470 480
SEKQAVLNNL AEKARLTEEI LNQAPGIRCN PVQGAMYSFP RIHIPEKAIK LAQAEGQAPD
490 500 510 520 530
MFFCMKLLEE TGICVVPGSG FGQREGTHHF RMTILPPTDK LKSLLERLKD FHQKFMDEYS