Q6GLW8
Gene name |
aifm2 |
Protein name |
Ferroptosis suppressor protein 1 |
Names |
FSP1, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:100049086 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6GLW8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6GLW8-F1 | Predicted | AlphaFoldDB |
No variants for Q6GLW8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6GLW8 | |||||
No associated diseases with Q6GLW8
1 regional properties for Q6GLW8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FAD/NAD(P)-binding domain | 12 - 298 | IPR023753 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSKVSVEES | VRVVIVGGGF | AGIAAASQLK | SFGIPFLLVD | MKDAFHHNVA | ALRACVESGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARKTFISYKD | SFHDSFKQGK | VVGINLQTQL | VILESNEELS | FSHLIIATGS | NGPFPGKFNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VISKDQAIQI | YENLVEEIQK | AKHVVVVGGG | SAGVEMAAEV | KTDYPEKEVT | LIHSKIALAD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQLQPSVRRT | VKEILLRKGV | RLILAQKVTN | LDQVTPNVAQ | ENMELQLDKD | SEVVNCDLVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CCIGLKVSSS | SYRSALGDKM | AEDGSLIVND | YLQVQGHENV | YAVGDCAYIN | EPKMAYYAGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HARVAATNVR | NSLIGKSLKS | YIPGALSMLL | SMGRNDGVGQ | FNGYYLGRCF | VTMAKSRDIF |
| 370 | |||||
| VSKSWKEMGQ | TMPR |