Q6G0K6

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
KEGG Pathway
bqu:BQ02440
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6G0K6

Entry ID Method Resolution Chain Position Source
AF-Q6G0K6-F1 Predicted AlphaFoldDB

No variants for Q6G0K6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6G0K6

No associated diseases with Q6G0K6

4 regional properties for Q6G0K6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 64 - 75 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 35 - 680 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 725 - 871 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 681 - 856 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVKNETIDY SKTLYLPQTN FPMRGRLPQK ELELIARWDN MGLYAQLRQQ AKDRPLYILH
70 80 90 100 110 120
DGPPYANGHI HIGHALNKVL KDVIIRSFQM RGFNANYVPG WDCHGLPIEW KIEEKYRAQG
130 140 150 160 170 180
KNKDDVPLNE FRQECREFAK YWITVQSEEF KRLGVVGDFN SPYTTMAFHA EARIASELMK
190 200 210 220 230 240
FAMSGQIYRG SKPVMWSVVE RTALAEAEIE YHDYESEVIW VKFPVLQADS SDLCGAYVVI
250 260 270 280 290 300
WTTTPWTIPG NRAVSYSSQI SYGVYEVAST QNDFGPQVGE RLLFADALAM SCAEKAKLVL
310 320 330 340 350 360
KRLRIISADE LKTLFLFHPL KGFAGSYNDK IAMLDGAHVT ENAGTGFVHT APSHGREDFE
370 380 390 400 410 420
IWNAYKPLLE QFGIDSSIPF PVDDAGFYTK DAPGFGPNRE GGAVRVIDDN GKMGDANKEV
430 440 450 460 470 480
INALIKADRL FARGRLKHSY PHSWRSKKPV IFRNTPQWFI SMDKDLGDGS TLRSRALEAV
490 500 510 520 530 540
SMTRFVPSSG QSRLASMIAD RPDWVLSRQR AWGVPICIFA NEDGVILKDE RVNERILRAF
550 560 570 580 590 600
EAEGADAWFA EGARERFLGE RAHESWVQVL DILDVWFDSG ASHSFVLEDR DDLKWPADVY
610 620 630 640 650 660
FEGSDQHRGW FQSSLLESCG TRACSPYKAV ITHGFTLDEN GKKMSKSLGN TVVPQEIIKT
670 680 690 700 710 720
SGADIFRLWV MTTDYWEDQR LGKQILQTNM DLYRKLRNAI RWMLGILAHD EGEKISYCAL
730 740 750 760 770 780
PDLEKFILHQ LFELDQLINR AYDEFDFKKI MRALLDFSIT ELSAFYFDIR KDSLYCDAPS
790 800 810 820 830 840
SKKRKASLQV IREIFERMVI WLAPMLPFTM EEAWLEHSPK SHSVHLEQFR SVPGEWQNGF
850 860 870 880 890 900
LAERWRKVRQ VRKVVTGALE FERAAKRIGS SLEAAPIVFI SNPVLLEALE NLDMAEICIT
910 920 930 940 950 960
SALTITQDVP PSDAFILSDV EGVGVYPGKA LGTKCARSWR YTQDVGSDPA YPDVSARDAA
970
ALRELQMLGK I