Q6FXQ5

PR
Gene name
GPI14 (CAGL0B03905g)
Protein name
GPI mannosyltransferase 1
Names
GPI mannosyltransferase I, GPI-MT-I, Glycosylphosphatidylinositol-anchor biosynthesis protein 14
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0B03905g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

382-431 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FXQ5

Entry ID Method Resolution Chain Position Source
AF-Q6FXQ5-F1 Predicted AlphaFoldDB

No variants for Q6FXQ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FXQ5

No associated diseases with Q6FXQ5

No regional properties for Q6FXQ5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6FXQ5

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
glycosylphosphatidylinositol-mannosyltransferase I complex A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
alpha-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage.
glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.

2 GO annotations of biological process

Name Definition
fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFKLGTIGLL SLAVLLRIAF FLFGVYQDEH FTVKYTDIDY QVFNDAAWFV AHRKSPYNRD
70 80 90 100 110 120
TYRYTPLLSW LLLPNHMIPW FHFGKLIFVL CDLATGVLIL QMLKKLKSKY RYGTDRMTIM
130 140 150 160 170 180
AAIWLLNPMV ITISTRGNAE SVLCFLILSF LYCFLCEQYL LGGLLFGLSI HFKIYPIIYA
190 200 210 220 230 240
LPIAIYVAAA HYNKTQSVFK SSFKLFLVGF STLIVLILLT VFMYMLYGDK FIDQTYLYHI
250 260 270 280 290 300
YRTDHRHNFS VWNMLLYFNS ALPKTSELSK FVFLPQMIIV LAISLTQLRR PSSFPLLCNV
310 320 330 340 350 360
LFLETFAFVT FNKVCTSQYF IWYLIFLPFV LYNTRISMRR GIVMLVVWVA TQALWLRQGY
370 380 390 400 410 420
LLEFEGQNVF YPGLFCASVG FFVSNAWILG QFIEDTIIQN DYVYRIEPSE SRSKDSAVID
430
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