Q6FWQ2

PR
Gene name
EST3 (CAGL0C03828g)
Protein name
Telomere replication protein EST3
Names
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0C03828g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FWQ2

Entry ID Method Resolution Chain Position Source
AF-Q6FWQ2-F1 Predicted AlphaFoldDB

No variants for Q6FWQ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FWQ2

No associated diseases with Q6FWQ2

4 regional properties for Q6FWQ2

Type Name Position InterPro Accession
domain GNAT domain 414 - 565 IPR000182
domain Elp3/MiaA/NifB-like, radical SAM core domain 107 - 369 IPR006638
domain Radical SAM 55 - 564 IPR007197
domain Radical SAM, C-terminal extension 331 - 409 IPR032432

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

3 GO annotations of molecular function

Name Definition
DNA/RNA helicase activity Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
telomeric DNA binding Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.

2 GO annotations of biological process

Name Definition
positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
telomere maintenance via telomerase The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPFIPKSRS NAVESVYLHG WVRDMLLESK TSQNIAVIPR VDPDEASIPL LSRRIYANRR
70 80 90 100 110 120
HFVKITKFFQ VHNYSVYASV KDSQHQILSQ FTPKCVSEFE SRNRSRITSD TVNTLFMIGD
130 140 150 160 170
AKLGIMVVDE LRHYFGEKIV SLFNGLDMPY IPYLIINQAF ILDYDQVEAF KMTPFVYQYI