Q6FTG1

PR
Gene name
DPH1 (CAGL0G02761g)
Protein name
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Names
Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0G02761g
EC number
2.5.1.108: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FTG1

Entry ID Method Resolution Chain Position Source
AF-Q6FTG1-F1 Predicted AlphaFoldDB

No variants for Q6FTG1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FTG1

No associated diseases with Q6FTG1

6 regional properties for Q6FTG1

Type Name Position InterPro Accession
domain Helicase, C-terminal 378 - 545 IPR001650
domain Tudor domain 905 - 1014 IPR002999
domain Helicase-associated domain 565 - 666 IPR007502
domain DEAD/DEAH box helicase domain 139 - 296 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 132 - 327 IPR014001
domain Tudor domain-containing protein 9, Tudor domain 906 - 1006 IPR047384

Functions

Description
EC Number 2.5.1.108 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine- = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

1 GO annotations of biological process

Name Definition
peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDNTTEKKEP TKVPRRRFVG KRKTDGKTIT TVKADGNEVV RQTKSRVHVG RSLNHIPDDI
70 80 90 100 110 120
MEDEELNEAI KLLPQNYNFE IHKTVWNIRK HGAKRVALQM PEGLLIYSLL ISDILEQFCN
130 140 150 160 170 180
VETVVMGDVS YGACCIDDFT ARALDCDFIV HYAHSCLVPI DITEIKVLYV FVTIAIDETH
190 200 210 220 230 240
VIKTLQKNFP KGSRLATFGT IQFNPTVHSI KDTLLNDKEH MLYIVTPQIK PLSRGEVLGC
250 260 270 280 290 300
TSERLDKNQF DAMVFIGDGR FHLESSMIHN PEIPAFKYDP YNRKFTRERY DQKQLVQVRG
310 320 330 340 350 360
EALQVAQKGK VFGLILGALG RQGNVDTVRN LEEKLIKAGK TVVKIILSEI FPQKLAKFDK
370 380 390 400 410 420
IDVFVQVACP RLSIDWGYAF PKPLLTPYEA NVLLNHDVMF SEEYYPMDYY ETNGYGRGRI
PEHALVKN