Q6FRT2

PR
Gene name
CCR4 (CAGL0H06149g)
Protein name
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
Names
Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0H06149g
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6FRT2

Entry ID Method Resolution Chain Position Source
AF-Q6FRT2-F1 Predicted AlphaFoldDB

No variants for Q6FRT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6FRT2

No associated diseases with Q6FRT2

5 regional properties for Q6FRT2

Type Name Position InterPro Accession
domain TolB, N-terminal 23 - 126 IPR007195
repeat WD40-like beta propeller 207 - 236 IPR011659-1
repeat WD40-like beta propeller 248 - 283 IPR011659-2
repeat WD40-like beta propeller 292 - 327 IPR011659-3
repeat WD40-like beta propeller 336 - 369 IPR011659-4

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
CCR4-NOT core complex The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.
Cdc73/Paf1 complex A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
DNA replication checkpoint signaling A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
replication fork protection Any process that prevents the collapse of stalled replication forks.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDISMMGYP GMGQQQPQPQ QAQQPQQQPI SMQPHTMMNM MNTNLPPPGM MMGGAGSNTG
70 80 90 100 110 120
NENMINHGLM SGNPVSGIPN NNSHQLLDQL INKNPNNMGI PQQQQDSLAA QMQLPMGGMP
130 140 150 160 170 180
MGNGSAHNGN VGMNNNNTGG NNNIPMGNAN VLRNNNIIGN LGGSSLAGGN MNSGMPGIST
190 200 210 220 230 240
FGNTPGQLAA PPIQPNANAN NPMYHPHLED PSLMNNPIWK LQLQLATVSA QSVGQPNIYA
250 260 270 280 290 300
RQNAMKKYLA TQVPPQNQTQ QQAQAQSQIA ETSKSLVDCT KQALMDIMAP DDSKLKGMSA
310 320 330 340 350 360
PNTASTTTNS TISTPTTSKI DMNNSREQPS TPSLLLQHKK LSQYSIDEDD EVENRMVAPK
370 380 390 400 410 420
DTKYNDQIWH AIDLSNLQIF NISPNLMKYD FLTRLYLNGN GLESIPSSIR NLKNLRVLDL
430 440 450 460 470 480
SHNKLKELPK EIGNCYQLKY LYFFDNQITT LPWELGNLCN IQFLGCEGNP LDKELLKILT
490 500 510 520 530 540
EKSFTGLIFY LRDNRPEVPY PHDRKFIEIN ADGEPEKEYD TVQEAERNLS SDMQKKSFTM
550 560 570 580 590 600
LSYNTLCQHY ATPKMYRYTP SWALSWDYRR EKLKEQILNF NTDIICLQEV EAKTFEDFWQ
610 620 630 640 650 660
PLLEKHGYTG LFHAKTRAKT MQSKDSKKVD GCCAFYKTSK FKMLFKECVD FSGLWMKHKK
670 680 690 700 710 720
FQRTEDYLNR AMNKDNVAIV MKLQHIQSGE IMWLVTTHLH WDPKFNDVKT FQVGVLLDHM
730 740 750 760 770 780
ETLLKEQNPK QDVKKYPLVI CGDLNSYLSS SVYELFSTGR VQHHHDGKDR DFGYFSEDNF
790 800 810 820 830 840
SHNLALKSSY NCIGELAFTN FTPSFTDVID YIWFSSQALR VRGLLGEVDS EYVSNFIGFP
850 860 870
NDKFPSDHIP LLGRYEFLKS NNTQNSNSGS RKV